fosphenytoin

Known as: Fosphenytoine, fosphenytoin [Chemical/Ingredient], 3-(hydroxymethyl)phenytoin phosphate ester 
A water-soluble phosphate ester prodrug of phenytoin, a hydantoin derivative with anticonvulsant activity. Fosphenytoin is hydrolyzed to phenytoin by… (More)
National Institutes of Health

Topic mentions per year

Topic mentions per year

1994-2018
0102019942018

Papers overview

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Highly Cited
2010
Highly Cited
2010
BACKGROUND Anti-epileptic drugs are commonly used for seizure prophylaxis after neurological injury. We performed a study… (More)
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2004
2004
STUDY OBJECTIVE Oral phenytoin, intravenous phenytoin, and intravenous fosphenytoin are all commonly used for loading phenytoin… (More)
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2003
2003
AIMS Status epilepticus is common in children with severe falciparum malaria and is associated with poor outcome. Phenytoin is… (More)
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2003
2003
OBJECTIVES Since several anticonvulsants are therapeutic in mania and since acute mania requires rapid and intensive treatment… (More)
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1999
1999
PURPOSE The pharmacokinetic behavior of fosphenytoin (FOS), the water-soluble prodrug of phenytoin (PHT), has been characterized… (More)
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1999
1999
We developed a pharmacoeconomic model to compare costs and clinical outcomes of administering phenytoin and fosphenytoin alone… (More)
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1999
1999
PURPOSE This study was designed to measure the brain penetration of phenytoin (PHT) after intravenous (i.v.) administration of… (More)
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1998
1998
In comparison with phenytoin preparations, which have a pH value of 11, fosphenytoin, a phosphorylated prodrug of phenytoin, has… (More)
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1996
1996
STUDY OBJECTIVE To evaluate the safety, tolerability, and pharmacokinetic profile of fosphenytoin, a water-soluble phenytoin… (More)
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1994
1994
STUDY OBJECTIVE To compare the frequency, severity, and time course of venous irritation after administration of a single… (More)
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