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A comparison of four treatments for generalized convulsive status epilepticus. Veterans Affairs Status Epilepticus Cooperative Study Group.
As initial intravenous treatment for overt generalized convulsive status epilepticus, lorazepam is more effective than phenytoin and it is easier to use. Expand
New onset geriatric epilepsy
LTG and GBP should be considered as initial therapy for older patients with newly diagnosed seizures, and patients taking lamotrigine (LTG) or gabapentin (GBP) did better than those taking carbamazepine. Expand
Double-blind study of lorazepam and diazepam in status epilepticus.
Seizures were controlled in 89% of the episodes treated with lorazepam and in 76% treated with diazepam and the times for onset of action of the medications did not differ significantly. Expand
Epidemiological and medical aspects of epilepsy in the elderly
Management of the older patient with epilepsy requires an understanding of the etiologies and the medical and psychological aspects unique to this age group. Expand
Topiramate placebo-controlled dose-ranging trial in refractory partial epilepsy using 200-, 400-, and 600-mg daily dosages
Results of this initial well-controlled study in patients indicate that topiramate is a very promising new AED. Expand
Treatment of epilepsy by stimulation of the vagus nerve
Most patients tolerated the device and stimulation well, and two patients have been seizure-free for over 1 year and some cases of medically refractory partial seizures are improved by vagal stimulation. Expand
Effects of vagus nerve stimulation on amino acids and other metabolites in the CSF of patients with partial seizures
There were significant correlations between seizure reduction and increases in asparagine, phenylalanine, PEA, alanine and tryptophan concentrations and Chronic VNS appears to have an effect on various amino acids pools in the brain. Expand
Vagus Nerve Stimulation for Treatment of Partial Seizures: 2. Safety, Side Effects, and Tolerability
Summary: Vagus nerve stimulation (VNS) significantly reduces the frequency of partial seizures in refractory epilepsy patients. We examined the serious adverse events, side effects, and tolerabilityExpand
Treatment of Status Epilepticus
Status epilepticus, particularly the convulsive form, is a medical emergency, warranting prompt and aggressive treatment, and one must have a thorough understanding of the pharmacology of the anticonvulsant agents to establish and adhere to a standard treatment protocol. Expand
Special considerations in treating the elderly patient with epilepsy
Data on efficacy and safety from clinical trials of newer antiepileptic drugs (AEDs) in elderly patients compared with older AEDs is presented and the implications of the findings using newer-generation Aeds in the Veterans Affairs Cooperative Study (VACS) #428 are discussed in order to educate physicians involved in choosing appropriate AEDS for older patients. Expand