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folylpolyglutamate synthase activity

Known as: tetrahydrofolate:L-glutamate gamma-ligase (ADP-forming) activity, N(10)-formyltetrahydropteroyldiglutamate synthetase activity, tetrahydrofolate synthase activity 
Catalysis of the reaction: ATP + tetrahydrofolyl-(Glu)(n) + L-glutamate = ADP + phosphate + tetrahydrofolyl-(Glu)(n+1). [EC:6.3.2.17]
National Institutes of Health

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tetrahydrofolylpolyglutamate biosynthetic process

Papers overview

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2004
2004
Inactivation of the Leishmania tarentolae Pterin Transporter (BT1) and Reductase (PTR1) Genes Leads to Viable Parasites with Changes in Folate Metabolism and Hypersensitivity to the Antifolate…
The protozoan parasite Leishmania is a folate and pterin auxotroph. The main biopterin transporter (BT1) and pterin reductase… 
1999
1999
Variable intrinsic sensitivity of human tumor cell lines to raltitrexed (Tomudex) and folylpolyglutamate synthetase activity.
The cytotoxic effects of Tomudex (TX) were investigated on a panel of 15 human tumor cell lines expressing a spontaneous… 
1997
1997
Folylpolyglutamate synthase from higher plants.
1996
1996
Dietary folate and folylpolyglutamate synthetase activity in normal and neoplastic murine tissues and human tumor xenografts.
1991
1991
Mutagenesis of the folC gene encoding folylpolyglutamate synthetase-dihydrofolate synthetase in Escherichia coli.
1990
1990
Preferential selection during therapy in vivo by edatrexate compared to methotrexate of resistant L1210 cell variants with decreased folylpolyglutamate synthetase activity.
Acquired resistance of the L1210 leukemia in mice developed with less rapidity during therapy with edatrexate (10-ethyl-10… 
Highly Cited
1987
Highly Cited
1987
Mammalian folylpoly-gamma-glutamate synthetase. 4. In vitro and in vivo metabolism of folates and analogues and regulation of folate homeostasis.
The regulation of folate and folate analogue metabolism was studied in vitro by using purified hog liver folylpolyglutamate… 
1987
1987
Liver folylpolyglutamate synthetase activity in folic acid-deficient rats.
To investigate the influence of folate deficiency on the addition process of glutamyl unit to folylpolyglutamates, liver… 
1986
1986
Methotrexate analogues. 26. Inhibition of dihydrofolate reductase and folylpolyglutamate synthetase activity and in vitro tumor cell growth by methotrexate and aminopterin analogues containing a…
Analogues of the antitumor antifolate methotrexate (MTX) were synthesized in which the glutamate (Glu) moiety was replaced by… 
1986
1986
In situ autoradiographic detection of folylpolyglutamate synthetase activity.
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