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folylpolyglutamate synthase activity

Known as: tetrahydrofolate:L-glutamate gamma-ligase (ADP-forming) activity, N(10)-formyltetrahydropteroyldiglutamate synthetase activity, tetrahydrofolate synthase activity 
Catalysis of the reaction: ATP + tetrahydrofolyl-(Glu)(n) + L-glutamate = ADP + phosphate + tetrahydrofolyl-(Glu)(n+1). [EC:6.3.2.17]
National Institutes of Health

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tetrahydrofolylpolyglutamate biosynthetic process

Papers overview

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2007
2007
Pharmacological and molecular investigations on the mechanisms underlying resistance of human leukaemia cells to the antimetabolites methotrexate, 6-mercaptopurine and 6-thioguanine
The goal of this thesis has been to elucidate the mechanisms underlying resistance to methotrexate (MTX), 6-mercaptopurine (6-MP… 
2006
2006
CCRF-CEM Cell Lines Derived from Human Lymphoblastic Leukemia Multifactorial Resistance to 5 , 10-Dideazatetrahydrofolic Acid in Updated Version
5,10-dideaza-5,6,7,8-terrahydrofolic acid (DDATHF) is a potent antiproliferative agent in cell culture systems and in vivo in a… 
2006
2006
Mechanism of Fluorouracil Resistance Decreased Folylpolyglutamate Synthetase Expression : A Novel Updated
HCT-8 cells become rapidly resistant to either 4-h (HCT-8/4hR) or 7-day (HCT-8/7dR) repeated exposures to fluorouracil (FUra… 
1999
1999
Variable intrinsic sensitivity of human tumor cell lines to raltitrexed (Tomudex) and folylpolyglutamate synthetase activity.
The cytotoxic effects of Tomudex (TX) were investigated on a panel of 15 human tumor cell lines expressing a spontaneous… 
1993
1993
Characterization of dihydrofolate synthetase from neurospora crassa wild type and its resolution from folylpolyglutamate synthetase activity
Highly Cited
1987
Highly Cited
1987
Mammalian folylpoly-gamma-glutamate synthetase. 4. In vitro and in vivo metabolism of folates and analogues and regulation of folate homeostasis.
The regulation of folate and folate analogue metabolism was studied in vitro by using purified hog liver folylpolyglutamate… 
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