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Methotrexate resistance in an in vivo mouse tumor due to a non-active-site dihydrofolate reductase mutation.
A series of methotrexate (MTX)-resistant L1210 leukemia murine ascites tumors were developed in vivo and analyzed for drug resistance. Three of 20 tumors studied expressed an altered dihydrofolateExpand
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New folate analogs of the 10-deaza-aminopterin series: markedly increased antitumor activity of the 10-ethyl analog compared to the parent compound and methotrexate against some human tumor
In an extension of our prior studies in murine tumor models, we examined two new folate analogs in the 10-deaza-aminopterin series for antitumor activity against a group of human tumor xenografts inExpand
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Mutagenic and chemotherapeutic activity in L1210 leukemia of several monofunctional alkylating agents.
The mutagenic and chemotherapeutic activities of the following monofunctional alkylating agents were compared in vivo: beta-chloroethylamine, dimethyl- and diethylaminoethyl chloride; methyl- andExpand
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Studies on analogues of classical antifolates bearing the naphthoyl group in place of benzoyl in the side chain.
Analogues of classical antifolates with the 4-aminobenzoyl group replaced by 4-amino-1-naphthoyl were synthesized for study after molecular modeling indicated ample spatial accommodation for theExpand
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Schedule-dependent synergism of taxol or taxotere with edatrexate against human breast cancer cells in vitro
A new dihydrofolate reductase inhibitor, edatrexate (EDX), and the microtubule polymerization promotor, taxol (TXL) or taxotere (TXT), each have significant therapeutic activity against human breastExpand
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9-substituted acridine derivatives with long half-life and potent antitumor activity: synthesis and structure-activity relationships.
A series of DNA-intercalating 9-anilinoacridines, namely 9-phenoxyacridines, 9-(phenylthio)acridines, and 9-(3',5'-disubstituted anilino)acridines, were synthesized as potential antitumor agents withExpand
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Differential uptake of 1-(2-chloroethyl)-3-(trans-4-methylcyclohexyl)-1-nitrosourea and doxorubicin by Lewis lung carcinoma and Ridgway osteogenic sarcoma.
Abstract 1-(2-Chloroethyl)-3-( trans -4-methylcyclohexyl)-1-nitrosourea (MeCCNU), a lipophilic substance, is therapeutically effective against many murine tumors, especially Lewis lung carcinomaExpand
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Eicosanoids and metastasis: experimental aspects in Lewis lung carcinoma.
Lewis lung primary carcinomas have been extracted for eicosanoids, and the findings examined in relation to lung metastases. The order of the 5 compounds measured was PGE2 greater than PGE1 greaterExpand
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Combination chemotherapy with a new folate analog: activity of 10-ethyl-10-deaza-aminopterin compared to methotrexate with 5-fluorouracil and alkylating agents against advanced metastatic disease in
A new folate analog, 10-ethyl-10-deaza-aminopterin (10EDAM), was compared to methotrexate (MTX) in combination with 5-fluorouracil (5-FU) and/or alkylating agents against three models of advancedExpand
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