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fiacitabine

Known as: 2(1H)-pyrimidinone, 4-amino-1-(2-deoxy-2-fluoro-beta-D-arabinofuranosyl)-5-iodo-, 2'-fluoro-5-iodo-1-beta-D-arabinofuranosylcytosine, FIAC 
A pyrimidine nucleoside analog with activity against various herpesviruses. Fiacitabine is converted to its triphosphate form in vivo and inhibits… 
National Institutes of Health

Related topics

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4 relations

Broader (3)

Antineoplastic AgentsAntiviral AgentsCytarabine
analogs & derivatives

Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
Review
1995
Review
1995
COMMITTEE TO REVIEW THE FIALURIDINE (FIAU/FIAC) CLINICAL TRIALS
1987
1987
Nucleosides. 139. Synthesis and anticytomegalovirus and antiherpes simplex virus activity of 5'-modified analogues of 2'-fluoroarabinosylpyrimidine nucleosides.
In order to determine if modification of the 5'-position reduces or abolishes the antiviral activity of 2'-fluoro-5-iodo-ara-C… 
1986
1986
2'-Fluoro-5-iodoarabinosylcytosine, a new potent antiviral agent: efficacy in immunosuppressed individuals with herpes zoster.
2'-Fluoro-5-iodoarabinosylcytosine (FIAC) has potent antiviral activity in vivo against herpes simplex virus types 1 and 2 and… 
1986
1986
Enzymology and pathogenicity in mice of a herpes simplex virus type 1 mutant resistant to 2'-fluoro-2'-deoxy-1-beta-D-arabinofuranosyl-5-iodocytosine
The deoxypyrimidine nucleoside analog 2'-fluoro-2'-deoxy-1-beta-D-arabinofuranosyl-5-iodocytosine (FIAC) is a potent and… 
1985
1985
Nucleosides. 133. Synthesis of 5-alkenyl-1-(2-deoxy-2-fluoro-beta-D-arabinofuranosyl)cytosines and related pyrimidine nucleosides as potential antiviral agents.
The synthesis of 1-(2-deoxy-2-fluoro-beta-D-arabinofuranosyl)cytosines with a halovinyl or vinyl substituent at C-5 was… 
1985
1985
Biotransformation and elimination of [2-14C]-1-(2-deoxy-2'-fluoro-beta-D -arabinofuranosyl)-5-iodocytosine in immunosuppressed patients with herpesvirus infections
The metabolism of the drug [2-14C]-1-(2'-deoxy-2'-fluoro-beta-D -arabinofuranosyl)-5-iodocytosine (FIAC), a potent inhibitor of… 
1985
1985
Antiviral activity of 2'-deoxy-2'-fluoro-beta-D-arabinofuranosyl-5-iodocytosine against human cytomegalovirus in human skin fibroblasts
2'-Deoxy-2'-fluoro-beta-D-arabinofuranosyl-5-iodocytosine (FIAC) was shown to be a selective anti-human cytomegalovirus agent in… 
1984
1984
Effects of certain nucleoside analogues on human cytomegalovirus replication in vitro.
Four nucleoside analogues, 1-(2'-deoxy-2'-fluoro-beta-D-arabinofuranosyl)-5-methyluracil (FMAU), -5-iodouracil (FIAU), -5… 
1984
1984
Treatment of primary acute genital herpes in guinea pigs by intraperitoneal administration of fluoropyrimidines
FIAC [1-(2'-deoxy-2'-fluoro-beta-D-arabinofuranosyl)-5-iodocytosine], FIAU [1-(2'-deoxy-2'-fluoro-beta-D-arabinofuranosyl)-5… 
Highly Cited
1983
Highly Cited
1983
Distribution, Metabolism, and Excretion of 1-(2-Fluoro-2-deoxy-β-d-arabinofuranosyl)thymine and 1-(2-Fluoro-2-deoxy-β-d-arabinofuranosyl)-5-iodocytosine
1-(2-Fluoro-2-deoxy-β-d-arabinofuranosyl)thymine (FMAU) and 1-(2-fluoro-2-deoxy-β-d-arabinofuranosyl)-5-iodocytosine (FIAC) are… 
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