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Exatecan mesylate is a hexacyclic, water-soluble, topoisomerase-1 inhibitor. Exatecan has single-agent and combination… Expand 4006 BACKGROUND: DX is a novel hexacyclic, water-soluble, topoisomerase-1 inhibitor. DX has single-agent and combination activity… Expand We determined the antitumor and antimetastatic efficacy of the camptothecin analogue DX-8951f in an orthotopic metastatic mouse… Expand The objective of the current study was to determine the antitumor activity, safety, and pharmacokinetic (PK) profile of exatecan… Expand BackgroundDX-8951f is a water-soluble camptothecin derivative with greater in vivo and in vitro activity than topotecan or… Expand The camptothecins are a maturing class of anticancer agents. In this article, we review the pharmacology and antitumor activity… Expand PURPOSE
DX-8951f is a novel hexacyclic camptothecin-analogue topoisomerase I inhibitor with both in vitro antileukemic activity… Expand PURPOSE
A Phase I study of exatecan, a new water-soluble camptothecin derivative, was conducted to determine the maximum… Expand PURPOSE
To determine the maximum-tolerated dose (MTD), dose-limiting toxicity (DLT), pharmacokinetic (PK) profile, and… Expand Exatecan mesylate (DX-8951f) is a topoisomerase I inhibitor that has increased solubility and antitumor activity compared with… Expand