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exatecan mesylate

Known as: (1S,9S)-1-amino-9-ethyl-5-fluoro-2,3-dihydro-9-hydroxy-4-methyl-1H,12H-benzo(de)pyrano(3',4'-6,7)indolizino(1,2-b)quinoline-10,13(9H,15H)dione methanesulfonate, Exatecan Mesylate Hydrate 
A semisynthetic, water-soluble derivative of camptothecin with antineoplastic activity. Exatecan mesylate inhibits topoisomerase I activity by… Expand
National Institutes of Health

Papers overview

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Highly Cited
2006
Highly Cited
2006
PURPOSE Exatecan mesylate is a hexacyclic, water-soluble, topoisomerase-1 inhibitor. Exatecan has single-agent and combination… Expand
Is this relevant?
2005
2005
Purpose: To determine the anti-tumor activity DX-8951f when administered as a 30-minute infusion daily for 5 days every 3 weeks… Expand
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Highly Cited
2004
Highly Cited
2004
4006 BACKGROUND: DX is a novel hexacyclic, water-soluble, topoisomerase-1 inhibitor. DX has single-agent and combination activity… Expand
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Highly Cited
2003
Highly Cited
2003
We determined the antitumor and antimetastatic efficacy of the camptothecin analogue DX-8951f in an orthotopic metastatic mouse… Expand
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2003
2003
The objective of the current study was to determine the antitumor activity, safety, and pharmacokinetic (PK) profile of exatecan… Expand
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2003
2003
BackgroundDX-8951f is a water-soluble camptothecin derivative with greater in vivo and in vitro activity than topotecan or… Expand
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2002
2002
PURPOSE DX-8951f is a novel hexacyclic camptothecin-analogue topoisomerase I inhibitor with both in vitro antileukemic activity… Expand
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2001
2001
PURPOSE To determine the maximum-tolerated dose (MTD), dose-limiting toxicity (DLT), pharmacokinetic (PK) profile, and… Expand
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2001
2001
PURPOSE A Phase I study of exatecan, a new water-soluble camptothecin derivative, was conducted to determine the maximum… Expand
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2001
2001
Exatecan mesylate (DX-8951f) is a topoisomerase I inhibitor that has increased solubility and antitumor activity compared with… Expand
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