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The synthesis and NMDA receptor affinity of ring and side-chain homologues of etoxadrol and dexoxadrol are described. For the… Expand A series of dioxolane analogues based on dexoxadrol ((4S,6S)-2,2-diphenyl-4-(2-piperidyl)-1,3-dioxolane) and etoxadrol ((2S,4S,6S… Expand The excitatory amino acids L-glutamate and N-methyl-D-aspartate (NMDA) produced contractions of the myenteric plexus-longitudinal… Expand Abstract: The potent noncompetitive N‐methyl‐D‐aspartate (NMDA) receptor antagonist [3H]MK‐801 bound with nanomolar affinity to… Expand Representatives from several chemical classes known to share behavioral properties with phencyclidine [(1-phenylcyclohexyl… Expand Primarily on the basis of activity in [3H]phencyclidine (PCP) binding assays and drug discrimination studies, a number of… Expand In this study representatives from three chemical classes which are known to produce a phencyclidine (PCP)-like discriminative… Expand The binding of [3H]phencyclidine (PCP) to receptors in rat brain cortex has been studied. Two receptors have been detected, a… Expand Phencyclidine [(l-phenylcyclohexyl) piperidine] (PCP) is known to increase the basal efflux of striatal dopamine (DA) in vitro… Expand The effects of ketamine and etoxadrol an spinal reflexes were studied in the cat and the rat. At doses of 0.1 to 10 mg/kg, iv… Expand