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epothilone D

Known as: (4S-(4R*,7S,8R*,9R*,13Z,16R*(E)))-4,8-Dihydroxy-5,5,7,9,13-pentamethyl-16-(1-methyl-2-(2-methyl-4-thiazolyl)ethenyl)oxacyclohexadec-13-ene-2,6-dione, Desoxyepothilone B, (-)-desoxyepothilone B 
A natural polyketide compound isolated from the myxobacterium Sorangium cellulosum. Also known as desoxyepothilone B, epothilone D binds to tubulin… 
National Institutes of Health

Related topics

Related topics

5 relations

Broader (1)

Epothilones

Narrower (2)

KOS 862epothilone B
Microtubule ProcessNegative Regulation of Microtubule Depolymerization

Papers overview

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Highly Cited
2012
Highly Cited
2012
The Microtubule-Stabilizing Agent, Epothilone D, Reduces Axonal Dysfunction, Neurotoxicity, Cognitive Deficits, and Alzheimer-Like Pathology in an Interventional Study with Aged Tau Transgenic Mice
Neurodegenerative tauopathies, such as Alzheimer's disease (AD), are characterized by insoluble deposits of hyperphosphorylated… 
Highly Cited
2006
Highly Cited
2006
Paclitaxel-resistant cells have a mutation in the paclitaxel-binding region of β-tubulin (Asp26Glu) and less stable microtubules
Resistance to paclitaxel-based therapy is frequently encountered in the clinic. The mechanisms of intrinsic or acquired… 
Highly Cited
2006
Highly Cited
2006
Microtubule-targeting agents inhibit angiogenesis at subtoxic concentrations, a process associated with inhibition of Rac1 and Cdc42 activity and changes in the endothelial cytoskeleton
Conventional anticancer agents may display antiangiogenic effects, but the underlying mechanism is poorly understood. We… 
Highly Cited
2003
Highly Cited
2003
Suppression of microtubule dynamics by epothilone B is associated with mitotic arrest.
The epothilones are a group of novel microtubule-targeted, antimitotic compounds that have a paclitaxel-like, assembly enhancing… 
Highly Cited
2003
Highly Cited
2003
Microtubule alterations and mutations induced by desoxyepothilone B: implications for drug-target interactions.
Highly Cited
2003
Highly Cited
2003
Crystal Structures of Epothilone D-bound, Epothilone B-bound, and Substrate-free Forms of Cytochrome P450epoK*
Epothilones are potential anticancer drugs that stabilize microtubules by binding to tubulin in a manner similar to paclitaxel… 
Highly Cited
2001
Highly Cited
2001
Treatment with inhibitors of caspases, that are substrates of drug transporters, selectively permits chemotherapy-induced apoptosis in multidrug-resistant cells but protects normal cells
Many chemotherapeutic agents induce apoptosis in tumor cells, but killing of normal cells remains a major obstacle. Development… 
Highly Cited
1998
Highly Cited
1998
Desoxyepothilone B is curative against human tumor xenografts that are refractory to paclitaxel.
The epothilones are naturally occurring, cytotoxic macrolides that function through a paclitaxel (Taxol)-like mechanism. Although… 
Highly Cited
1998
Highly Cited
1998
Upregulation of caveolin‐1 and caveolae organelles in Taxol‐resistant A549 cells
Highly Cited
1998
Highly Cited
1998
Desoxyepothilone B: an efficacious microtubule-targeted antitumor agent with a promising in vivo profile relative to epothilone B.
A new class of 16-membered macrolides, the epothilones (Epos), has been synthesized and evaluated for antitumor potential in… 
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