epothilone D

Known as: (4S-(4R*,7S,8R*,9R*,13Z,16R*(E)))-4,8-Dihydroxy-5,5,7,9,13-pentamethyl-16-(1-methyl-2-(2-methyl-4-thiazolyl)ethenyl)oxacyclohexadec-13-ene-2,6-dione, Desoxyepothilone B, (-)-desoxyepothilone B 
A natural polyketide compound isolated from the myxobacterium Sorangium cellulosum. Also known as desoxyepothilone B, epothilone D binds to tubulin… (More)
National Institutes of Health

Papers overview

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2015
2015
Neuronal cytoskeletal alterations, in particular the loss and misalignment of microtubules, are considered a hallmark feature of… (More)
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Highly Cited
2012
Highly Cited
2012
Neurodegenerative tauopathies, such as Alzheimer's disease (AD), are characterized by insoluble deposits of hyperphosphorylated… (More)
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Highly Cited
2010
Highly Cited
2010
Neurons in the brains of those with Alzheimer's disease (AD) and many frontotemporal dementias (FTDs) contain neurofibrillary… (More)
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Highly Cited
2009
Highly Cited
2009
Multidrug resistance protein 7 (MRP7; ABCC10) is an ATP-binding cassette transporter which is able to transport amphipathic… (More)
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Highly Cited
2007
Highly Cited
2007
PURPOSE Ixabepilone (BMS-247550) is an epothilone analog that optimizes the properties of naturally occurring epothilone B… (More)
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Highly Cited
2006
Highly Cited
2006
Conventional anticancer agents may display antiangiogenic effects, but the underlying mechanism is poorly understood. We… (More)
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2006
2006
BACKGROUND Proteomic investigations have revealed alterations in cytoskeletal proteins expressed in human acute lymphoblastic… (More)
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Highly Cited
2003
Highly Cited
2003
The epothilones are a group of novel microtubule-targeted, antimitotic compounds that have a paclitaxel-like, assembly enhancing… (More)
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2003
2003
PURPOSE The epothilones are a novel class of nontaxane microtubule-stabilizing agents. BMS-247550 is a semisynthetic analog of… (More)
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2002
2002
Epothilones are potential anticancer drugs that stabilize microtubules in a manner similar to paclitaxel (Taxol). Epothilones are… (More)
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