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epothilone D

Known as: (4S-(4R*,7S,8R*,9R*,13Z,16R*(E)))-4,8-Dihydroxy-5,5,7,9,13-pentamethyl-16-(1-methyl-2-(2-methyl-4-thiazolyl)ethenyl)oxacyclohexadec-13-ene-2,6-dione, Desoxyepothilone B, (-)-desoxyepothilone B 
A natural polyketide compound isolated from the myxobacterium Sorangium cellulosum. Also known as desoxyepothilone B, epothilone D binds to tubulin… 
National Institutes of Health

Related topics

Related topics

5 relations

Broader (1)

Epothilones

Narrower (2)

KOS 862epothilone B
Microtubule ProcessNegative Regulation of Microtubule Depolymerization

Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
Review
2010
Review
2010
Synthesis of (Z)-trisubstituted olefins by decarboxylative grob-type fragmentations: epothilone D, discodermolide, and peloruside A.
Methyl-branched (Z)-trisubstituted olefins are found in many polyketides with interesting biological activity, such as epothilone… 
Highly Cited
2005
Highly Cited
2005
Cyclostreptin (FR182877), an antitumor tubulin-polymerizing agent deficient in enhancing tubulin assembly despite its high affinity for the taxoid site.
Cyclostreptin (FR182877), a bacterial natural product, was reported to have weak paclitaxel-like activity with tubulin but… 
2005
2005
The epothilone dilemma.
Because of their potent antitumor activity, drugs targeting microtubules are among the most commonly prescribed anticancer agents… 
Highly Cited
2003
Highly Cited
2003
Epothilone C macrolactonization and hydrolysis are catalyzed by the isolated thioesterase domain of epothilone polyketide synthase.
Epothilone C is produced by the combined action of one nonribosomal peptide synthetase (NRPS) and nine polyketide synthase (PKS… 
Highly Cited
2002
Highly Cited
2002
BINOLAM, a recoverable chiral ligand for bifunctional enantioselective catalysis: the asymmetric synthesis of cyanohydrins.
[reaction: see text] A new bifunctional catalytic system based on a monometallic aluminum complex is used for the efficient… 
Highly Cited
2002
Highly Cited
2002
Late activation of apoptotic pathways plays a negligible role in mediating the cytotoxic effects of discodermolide and epothilone B in non-small cell lung cancer cells.
Discodermolide and epothilone B are promising novel chemotherapeutic agentsthat induce cell death through potent stabilization of… 
2002
2002
Large-scale isolation and crystallization of epothilone D from Myxococcus xanthus cultures.
The introduction of the epothilone polyketide synthase (PKS) into Myxococcus xanthus has enabled the heterologous production of… 
2001
2001
On the interactivity of complex synthesis and tumor pharmacology in the drug discovery process: total synthesis and comparative in vivo evaluations of the 15-aza epothilones.
The total syntheses of 12,13,15-desoxy-15(S)-aza-epothilone B (aza-dEpoB; dEpoB-lactam) and 12,13,15-desoxy-15(R)-aza-epothilone… 
2000
2000
Total synthesis of epothilone B.
Highly Cited
1998
Highly Cited
1998
A Novel Aldol Condensation with 2-Methyl-4-pentenal and Its Application to an Improved Total Synthesis of Epothilone B.
The stabilization of the transition state through a favorable interaction between the double bond of 1 and the carbonyl group of… 
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