epothilone B

Known as: (4S-(4R*,7S,8R*,9R*,13Z,16R*(E)))-4,8-Dihydroxy-5,5,7,9,13-pentamethyl-16-(1-methyl-2-(2-methyl-4-thiazolyl)ethenyl)oxacyclohexadec-13-ene-2,6-dione, 12,13-desoxyepothilone B, PATUPILONE 
A compound isolated from the myxobacterium Sorangium cellulosum. Similar to paclitaxel, patupilone induces microtubule polymerization and stabilizes… (More)
National Institutes of Health

Papers overview

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Highly Cited
2015
Highly Cited
2015
After central nervous system (CNS) injury, inhibitory factors in the lesion scar and poor axon growth potential prevent axon… (More)
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Highly Cited
2004
Highly Cited
2004
We have previously reported that the microtubule stabilizing agents (MSAs) paclitaxel, epothilone B and discodermolide induce… (More)
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Highly Cited
2003
Highly Cited
2003
PURPOSE The purpose is to investigate whether STI571, through platelet-derived growth factor receptor inhibition, enhances the… (More)
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Highly Cited
2003
Highly Cited
2003
Histone deacetylase inhibitors induce hyperacetylation of the amino-terminal lysine residues of the core nucleosomal histones… (More)
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Highly Cited
2003
Highly Cited
2003
The epothilones are a group of novel microtubule-targeted, antimitotic compounds that have a paclitaxel-like, assembly enhancing… (More)
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2003
2003
The molecular mechanisms underlying the cell cycle growth-inhibitory and apoptotic effects of flavopiridol (FP) were determined… (More)
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Highly Cited
2002
Highly Cited
2002
Recent preclinical studies have shown that frequent administration in vivo of low doses of chemotherapeutic drugs ("metronomic… (More)
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Highly Cited
2001
Highly Cited
2001
BMS-247550, a novel epothilone derivative, is being developed by Bristol-Myers Squibb Company (BMS) as an anticancer agent for… (More)
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Highly Cited
1997
Highly Cited
1997
Epothilones A and B, natural products with minimal structural analogy to taxoids, have effects similar to those of paclitaxel… (More)
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Highly Cited
1997
Highly Cited
1997
Acquired resistance to paclitaxel can be mediated by P-glycoprotein or by alterations involving tubulin. We report two paclitaxel… (More)
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