eplerenone

Known as: eplerenon, 9,11alpha-Epoxy-17-hydroxy-3-oxo-17alpha-pregn-4-ene-7alpha,21-dicarboxylic acid, gamma-lactone, Methyl Ester, eplerenone [Chemical/Ingredient] 
A selective aldosterone receptor antagonist. Eplerenone binds to the mineralocorticoid receptor and blocks the binding of aldosterone, thereby… (More)
National Institutes of Health

Papers overview

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Highly Cited
2013
Highly Cited
2013
We read with interest the report from Richards and colleagues (1) on the potential interactions of abiraterone, eplerenone, and… (More)
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Highly Cited
2012
Highly Cited
2012
OBJECTIVES The purpose of this study was to analyze the incidence of new atrial fibrillation or flutter (AFF) in the EMPHASIS-HF… (More)
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Highly Cited
2011
Highly Cited
2011
BACKGROUND Mineralocorticoid antagonists improve survival among patients with chronic, severe systolic heart failure and heart… (More)
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Highly Cited
2008
Highly Cited
2008
Some antihypertensive agents may improve resistance artery remodeling in hypertensive patients whereas other agents may not, for… (More)
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Highly Cited
2004
Highly Cited
2004
This study compared the efficacy and tolerability of eplerenone and enalapril in 499 patients with stage 1 or 2 hypertension who… (More)
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Highly Cited
2003
Highly Cited
2003
BACKGROUND Elevated renin-angiotensin-aldosterone system activity correlates with left ventricular hypertrophy (LVH) and… (More)
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Highly Cited
2002
Highly Cited
2002
BACKGROUND Eplerenone, a selective aldosterone blocker (SAB) that is highly specific for the aldosterone receptor, has the… (More)
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Highly Cited
2002
Highly Cited
2002
BACKGROUND Previous studies have demonstrated the development of cardiac fibrosis in aldosterone (Aldo)-salt hypertensive rats… (More)
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Highly Cited
2001
Highly Cited
2001
The importance of aldosterone in the pathophysiology of chronic heart failure (HF) has been established in previous studies [1–4… (More)
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