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eplerenone

Known as: eplerenon, 9,11alpha-Epoxy-17-hydroxy-3-oxo-17alpha-pregn-4-ene-7alpha,21-dicarboxylic acid, gamma-lactone, Methyl Ester, eplerenone [Chemical/Ingredient] 
A selective aldosterone receptor antagonist. Eplerenone binds to the mineralocorticoid receptor and blocks the binding of aldosterone, thereby… 
National Institutes of Health

Related topics

Related topics

13 relations
Arterial Vasodilation [PE]Decreased Blood Pressure [PE]Diabetes Mellitus, Non-Insulin-DependentHypertensive disease

Narrower (1)

Inspra

Broader (2)

Mineralocorticoid Receptor AntagonistsSpironolactone

Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
2012
2012
Cisplatin-induced acute renal failure in mice is mediated by chymase-activated angiotensin-aldosterone system and interleukin-18.
Review
2010
Review
2010
Spironolactone Use in Heart Failure Patients With End‐Stage Renal Disease on Hemodialysis: Is It Safe?
Spironolactone is used in the treatment of cardiovascular disease, but is contraindicated in renal dysfunction due to the risk of… 
2008
2008
Aldosterone induces myofibroblastic transdifferentiation and collagen gene expression through the Rho-kinase dependent signaling pathway in rat mesangial cells.
2008
2008
Aldosterone modifies hemostasis via upregulation of the protein-C receptor in human vascular endothelium.
2005
2005
Effects of eplerenone on transcriptional factors and mRNA expression related to cardiac remodelling after myocardial infarction
Objective: To examine the effects of eplerenone, a selective aldosterone blocker, on cardiac function after myocardial infarction… 
Highly Cited
2004
Highly Cited
2004
Eplerenone Prevents Salt-Induced Vascular Remodeling and Cardiac Fibrosis in Stroke-Prone Spontaneously Hypertensive Rats
We examined the effect of different levels of salt intake on the role of aldosterone on cardiac and vascular changes in salt… 
Review
2004
Review
2004
Evolving role of aldosterone blockers alone and in combination with angiotensin-converting enzyme inhibitors or angiotensin II receptor blockers in hypertension management: a review of mechanistic…
2004
2004
Prediction of in vivo drug interactions with eplerenone in man from in vitro metabolic inhibition data
1. The inhibition kinetics of eplerenone (EP) 6β-hydroxylation by 10 drugs were determined in vitro using human liver microsomes… 
Review
2004
Review
2004
Pleiotropic actions of aldosterone and the effects of eplerenone, a selective mineralocorticoid receptor antagonist.
Aldosterone plays an important role in the pathogenesis of cardiovascular and renal disease that is independent of angiotensin II… 
Review
2003
Review
2003
Aldosterone as a target in congestive heart failure.
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