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The metabolic syndrome and cardiovascular risk a systematic review and meta-analysis.
- S. Mottillo, K. Filion, +6 authors M. Eisenberg
- Journal of the American College of Cardiology
- 28 September 2010
A systematic review and meta-analysis of the cardiovascular risk associated with the metabolic syndrome as defined by the 2001 NCEP and 2004 revised National Cholesterol Education Program definitions found the syndrome is associated with a 2-fold increase in cardiovascular outcomes and a 1.5- fold increase in all-cause mortality. Expand
Signal transduction mechanisms mediating the physiological and pathophysiological actions of angiotensin II in vascular smooth muscle cells.
Alterations of these highly regulated signaling pathways in vascular smooth cells may be pivotal in structural and functional abnormalities that underlie vascular pathological processes in cardiovascular diseases such as hypertension, atherosclerosis, and post-interventional restenosis. Expand
Clinical practice guidelines for the management of hypertension in the community a statement by the American Society of Hypertension and the International Society of Hypertension.
Clinical Practice Guidelines for the Management of Hypertension in the Community A Statement by the American Society of Hypertension and the International Society of Hypertension
Chronic Kidney Disease: Effects on the Cardiovascular System
Prevention and treatment of cardiovascular disease are major considerations in the management of individuals with chronic kidney disease, which may lead to increased morbidity and mortality as a result of cardiovascular events. Expand
Clinical Practice Guidelines for the Management of Hypertension in the Community
- Michael A. Weber, E. Schiffrin, +22 authors S. Harrap
- Journal of clinical hypertension
- 1 January 2014
This dissertation aims to provide a history of infectious disease in the neonatal intensive care unit and some of the techniques used, as well as some new approaches, that have been developed in the clinic in recent years. Expand
Recommendations for Improving and Standardizing Vascular Research on Arterial Stiffness: A Scientific Statement From the American Heart Association.
The field of arterial stiffness investigation, which has exploded over the past 20 years, has proliferated without logistical guidance for clinical and research studies, and questions that remain to be addressed in this field are addressed. Expand
Vascular Remodeling in Hypertension: Roles of Apoptosis, Inflammation, and Fibrosis
The resulting remodeling of small arteries may initially be adaptive, but eventually it becomes maladaptive and compromises organ function, contributing to cardiovascular complications of hypertension. Expand
Angiotensin-(1-7) Through Receptor Mas Mediates Endothelial Nitric Oxide Synthase Activation via Akt-Dependent Pathways
- W. Sampaio, R. A. D. Dos Santos, Raphael Faria-Silva, L. T. da Mata Machado, E. Schiffrin, R. Touyz
- Biology, Medicine
- 1 January 2007
It is demonstrated that Ang-(1-7), through Mas, stimulates eNOS activation and NO production via Akt-dependent pathways, and the importance of the Ang-( 1-7)/Mas axis as a putative regulator of endothelial function is highlighted. Expand
Expression of a Functionally Active gp91phox-Containing Neutrophil-Type NAD(P)H Oxidase in Smooth Muscle Cells From Human Resistance Arteries: Regulation by Angiotensin II
The results suggest that HVSMCs possess a functionally active gp91phox-containing neutrophil-like NAD(P)H oxidase, which is regulated by angiotensin II by inducing phosphorylation of p47phox, translocation of cytosolic subunits, and de novo protein synthesis. Expand
Mechanisms that participate in the reduced vasodilatory responses in endothelial dysfunction include reduced nitric oxide generation, oxidative excess, and reduced production of hyperpolarizing factor. Expand