enzalutamide

Known as: Benzamide, 4-(3-(4-cyano-3-(trifluoromethyl)phenyl)-5,5-dimethyl-4-oxo-2-thioxo-1-imidazolidinyl)-2-fluoro-N-methyl- 
An orally bioavailable, organic, non-steroidal small molecule targeting the androgen receptor (AR) with potential antineoplastic activity. Through a… (More)
National Institutes of Health

Papers overview

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Review
2017
Review
2017
Importance Prostate cancer is the most common cancer diagnosis made in men with more than 160 000 new cases each year in the… (More)
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Highly Cited
2014
Highly Cited
2014
Enzalutamide is an oral androgen-receptor inhibitor that prolongs survival in men with metastatic castration-resistant prostate… (More)
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Highly Cited
2014
Highly Cited
2014
BACKGROUND The androgen-receptor isoform encoded by splice variant 7 lacks the ligand-binding domain, which is the target of… (More)
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Highly Cited
2014
Highly Cited
2014
BACKGROUND Abiraterone, an androgen synthesis inhibitor, has been successfully used in the treatment of castration-resistant… (More)
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Highly Cited
2014
Highly Cited
2014
PURPOSE Enzalutamide, a second-generation antiandrogen, was recently approved for the treatment of castration-resistant prostate… (More)
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Highly Cited
2013
Highly Cited
2013
Persistent androgen receptor (AR) transcriptional activity underlies resistance to AR-targeted therapy and progression to lethal… (More)
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Highly Cited
2013
Highly Cited
2013
UNLABELLED Despite the impressive clinical activity of the second-generation antiandrogens enzalutamide and ARN-509 in patients… (More)
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Highly Cited
2013
Highly Cited
2013
BACKGROUND Androgen receptor (AR) signalling remains critically important in metastatic castration-resistant prostate cancer… (More)
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Highly Cited
2013
Highly Cited
2013
The androgen receptor (AR) is widely expressed in breast cancers and has been proposed as a therapeutic target in estrogen… (More)
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Highly Cited
2012
Highly Cited
2012
BACKGROUND Enzalutamide (formerly called MDV3100) targets multiple steps in the androgen-receptor-signaling pathway, the major… (More)
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