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eniluracil

Known as: 5-ethynyl-2,4(1H,3H)-Pyrimidinedione, 2,4(1H,3H)-Pyrimidinedione, 5-ethynyl-, ethynyluracil 
An orally-active fluoropyrimidine analogue. Eniluracil inhibits dihydropyrimidine dehydrogenase, the rate-limiting enzyme that catabolizes and… Expand
National Institutes of Health

Papers overview

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Highly Cited
2011
Highly Cited
2011
Commonly used metabolic labels for DNA, including 5-ethynyl-2′-deoxyuridine (EdU) and BrdU, are toxic antimetabolites that cause… Expand
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Review
2004
Review
2004
The fluorinated pyrimidines have played amajor role in the treatment of many common tumors since5-fluorouracil (5FU) was first… Expand
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Review
1999
Review
1999
Dihydropyrimidine dehydrogenase (DPD) is the initial, rate-limiting enzyme in the catabolism of 5-fluorouracil (5-FU). DPD has an… Expand
Review
1998
Review
1998
1. Painstaking progress in drug development is well illustrated by 5‐fluorouracil (5FU), originally designed 40 years ago as a… Expand
Review
1997
Review
1997
PURPOSE AND METHODS Although fluoropyrimidines, in particular, fluorouracil (5-FU) and fluorodeoxyuridine (FdUrd), are active… Expand
Highly Cited
1994
Highly Cited
1994
5-Ethynyluracil (EU; 776C85) is a potent inactivator of dihydropyrimidine dehydrogenase, the enzyme that rapidly degrades 5… Expand
1994
1994
5-Ethynyluracil (776C85) is a potent mechanism-based inactivator of dihydropyrimidine dehydrogenase (DPD), the enzyme that… Expand
Highly Cited
1993
Highly Cited
1993
5-Ethynyluracil (776C85), a potent, mechanism-based, irreversible inactivator (Porter et al., J Biol Chem 267:5236-5242, 1992) of… Expand
Highly Cited
1993
Highly Cited
1993
5-Ethynyluracil (5-EU, 776C85) is a mechanism-based irreversible inhibitor of dihydropyrimidine dehydrogenase (EC 1.3.1.2), the… Expand
Highly Cited
1992
Highly Cited
1992
Uracil analogues with appropriate substituents at the 5-position inactivated dihydropyrimidine dehydrogenase (DHPDHase). The… Expand