Skip to search formSkip to main contentSkip to account menu

eniluracil

Known as: 5-ethynyl-2,4(1H,3H)-Pyrimidinedione, 2,4(1H,3H)-Pyrimidinedione, 5-ethynyl-, ethynyluracil 
An orally-active fluoropyrimidine analogue. Eniluracil inhibits dihydropyrimidine dehydrogenase, the rate-limiting enzyme that catabolizes and… 
National Institutes of Health

Related topics

Related topics

7 relations
Dihydropyrimidine dehydrogenaseanalogs & derivativesethynyluracil/fluorouracil

Broader (2)

Enzyme InhibitorsUracil

Narrower (2)

GW776GW776C85

Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
2010
2010
A possible cause and remedy for the clinical failure of 5-fluorouracil plus eniluracil.
BACKGROUND Eniluracil is a potent inactivator of dihydropyrimidine dehydrogenase (uracil reductase), the enzyme that rapidly… 
2003
2003
Dihydropyrimidine dehydrogenase (DPD) rapidly regenerates after inactivation by eniluracil (GW776C85) in primary and metastatic colorectal cancer
PurposeCatabolism of 5-fluorouracil (5-FU) is primarily regulated by DPD. Inactivation of DPD using eniluracil is advantageous in… 
2003
2003
Augmentation of the antitumor activity of capecitabine by a tumor selective dihydropyrimidine dehydrogenase inhibitor, RO0094889
Capecitabine is an orally available fluoropyrimidine and is finally converted to 5‐FU selectively in tumor tissues. In our study… 
2002
2002
Comparative pharmacokinetic study of continuous venous infusion fluorouracil and oral fluorouracil with eniluracil in patients with advanced solid tumors.
PURPOSE To compare the pharmacokinetics of continuous venous infusion (CVI) fluorouracil (5-FU) with that of oral eniluracil/5-FU… 
2002
2002
Eastern Cooperative Oncology Group phase II trial (E4296) of oral 5-fluorouracil and eniluracil as a 28-day regimen in metastatic colorectal cancer.
Coadministration of eniluracil with 5-fluorouracil (5-FU) allows the oral absorption of small doses of 5-FU, resulting in… 
2002
2002
Estimation of the effect of food on the disposition of oral 5-fluorouracil in combination with eniluracil
Abstract.Aims: To determine the effect of food on the pharmacokinetics of 5-fluoruracil (5-FU) taken orally with eniluracil and… 
Review
2000
Review
2000
Pharmacology of Fluorinated Pyrimidines: Eniluracil
The pharmacological inactivation of dihydropyrimidine dehydrogenase (DPD)represents one strategy to improve 5-FU therapy, which… 
1999
1999
In vivo effect of 5-ethynyluracil on 5-fluorouracil metabolism determined by 19F nuclear magnetic resonance spectroscopy.
Biochemical modulation of 5-fluorouracil (5-FU) has been used over the past 20 years to improve the therapeutic efficacy of this… 
Review
1998
Review
1998
New drugs in the treatment of colorectal carcinoma
Treatment with 5‐fluorouracil (5‐FU) plus leucovorin has been the unofficial standard therapy for patients with colorectal… 
1995
1995
5-Ethynyluracil (776C85): effects on the antitumor activity and pharmacokinetics of tegafur, a prodrug of 5-fluorouracil.
We studied the effects of 5-ethynyluracil (776C85 and 776C), a potent mechanism-based inactivator of dihydropyrimidine… 
By clicking accept or continuing to use the site, you agree to the terms outlined in our Privacy Policy (opens in a new tab), Terms of Service (opens in a new tab), and Dataset License (opens in a new tab)