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eniluracil

Known as: 5-ethynyl-2,4(1H,3H)-Pyrimidinedione, 2,4(1H,3H)-Pyrimidinedione, 5-ethynyl-, ethynyluracil 
An orally-active fluoropyrimidine analogue. Eniluracil inhibits dihydropyrimidine dehydrogenase, the rate-limiting enzyme that catabolizes and… 
National Institutes of Health

Related topics

Related topics

7 relations
Dihydropyrimidine dehydrogenaseanalogs & derivativesethynyluracil/fluorouracil

Broader (2)

Enzyme InhibitorsUracil

Narrower (2)

GW776GW776C85

Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
2003
2003
Dihydropyrimidine dehydrogenase (DPD) rapidly regenerates after inactivation by eniluracil (GW776C85) in primary and metastatic colorectal cancer
PurposeCatabolism of 5-fluorouracil (5-FU) is primarily regulated by DPD. Inactivation of DPD using eniluracil is advantageous in… 
2002
2002
Comparative pharmacokinetic study of continuous venous infusion fluorouracil and oral fluorouracil with eniluracil in patients with advanced solid tumors.
PURPOSE To compare the pharmacokinetics of continuous venous infusion (CVI) fluorouracil (5-FU) with that of oral eniluracil/5-FU… 
Review
2000
Review
2000
Pharmacology of Fluorinated Pyrimidines: Eniluracil
The pharmacological inactivation of dihydropyrimidine dehydrogenase (DPD)represents one strategy to improve 5-FU therapy, which… 
1999
1999
In vivo effect of 5-ethynyluracil on 5-fluorouracil metabolism determined by 19F nuclear magnetic resonance spectroscopy.
Biochemical modulation of 5-fluorouracil (5-FU) has been used over the past 20 years to improve the therapeutic efficacy of this… 
1999
1999
Phase I study of eniluracil, a dihydropyrimidine dehydrogenase inactivator, and oral 5-fluorouracil with radiation therapy in patients with recurrent or advanced head and neck cancer.
5-Fluorouracil (5-FU) is an effective enhancer of radiation therapy (RT) in head and neck cancers. Due to rapid, predominantly… 
Review
1998
Review
1998
New drugs in the treatment of colorectal carcinoma
Treatment with 5‐fluorouracil (5‐FU) plus leucovorin has been the unofficial standard therapy for patients with colorectal… 
1997
1997
Dual modulation of 5-fluorouracil cytotoxicity using folinic acid with a dihydropyrimidine dehydrogenase inhibitor.
1996
1996
Dihydropyrimidine dehydrogenase inactivation and 5-fluorouracil pharmacokinetics: allometric scaling of animal data, pharmacokinetics and toxicodynamics of 5-fluorouracil in humans
Abstract The pharmacokinetics of 5-fluorouracil (5-FU) in different animal species treated with the dihy-dropyrimidine… 
1995
1995
5-Ethynyluracil (776C85): effects on the antitumor activity and pharmacokinetics of tegafur, a prodrug of 5-fluorouracil.
We studied the effects of 5-ethynyluracil (776C85 and 776C), a potent mechanism-based inactivator of dihydropyrimidine… 
1994
1994
5-Ethynyluracil (776C85): protection from 5-fluorouracil-induced neurotoxicity in dogs.
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