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eniluracil

Known as: 5-ethynyl-2,4(1H,3H)-Pyrimidinedione, 2,4(1H,3H)-Pyrimidinedione, 5-ethynyl-, ethynyluracil 
An orally-active fluoropyrimidine analogue. Eniluracil inhibits dihydropyrimidine dehydrogenase, the rate-limiting enzyme that catabolizes and… Expand
National Institutes of Health

Papers overview

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Highly Cited
2011
Highly Cited
2011
Commonly used metabolic labels for DNA, including 5-ethynyl-2′-deoxyuridine (EdU) and BrdU, are toxic antimetabolites that cause… Expand
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2010
2010
Nucleotide excision repair (NER) removes the major UV-photolesions from cellular DNA. In humans, compromised NER activity is the… Expand
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Highly Cited
2002
Highly Cited
2002
The prescribed dose of anticancer agents is most commonly calculated using body surface area as the only independent variable… Expand
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2002
2002
PURPOSE To compare the efficacy and tolerability of eniluracil (EU)/fluorouracil (5-FU) with that of 5-FU/leucovorin (LV) as… Expand
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Review
2000
Review
2000
Today, adjuvant 5-fluorouracil based therapy is known to significantly reduce the relapse rates and the risks of dying from… Expand
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2000
2000
PURPOSE To determine the maximum-tolerated dose (MTD), toxicities, and pharmacokinetics of oral fluorouracil (5-FU) administered… Expand
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Review
1999
Review
1999
Colorectal cancer is one of the most frequent malignancies and one of the greatest causes of cancer death in the Western world… Expand
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1999
1999
PURPOSE To determine the effect of eniluracil on colorectal tumor dihydropyrimidine dehydrogenase (DPD) activity. PATIENTS AND… Expand
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Review
1998
Review
1998
1. Painstaking progress in drug development is well illustrated by 5-fluorouracil (5FU), originally designed 40 years ago as a… Expand
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1998
1998
PURPOSE To determine the highest dose of fluorouracil (5-FU) that could be safely administered with Eniluracil (776C85; Glaxo… Expand
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