ecumicin
National Institutes of Health
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Comparison of the structures of ClpC1–ecumicin and ClpC1–rufomycin complexes reveals unique interactions that are relevant to…
The ohmyungsamycin and ecumicin natural product families are structurally related cyclic depsipeptides that display potent…
Addressing the urgent need to develop novel drugs against drug-resistant Mycobacterium tuberculosis (M. tb) strains, ecumicin…
The first total synthesis of the potent anti-mycobacterial cyclic depsipeptide natural product ecumicin is described. Synthesis…
Mycobacterium tuberculosis can remain dormant in the host, an ability that explains the failure of many current tuberculosis…
Keywords:
Oligopeptides;
1H iterative Full Spin Analysis (HiFSA);
Ecumicin;
Computational Iteration;
Structure elucidation
This report describes an approach using 1H NMR iterative full-spin analysis (HiFSA) to extract definitive structural information…
Natural products are valuable resources that provide a variety of bioactive compounds and natural pharmacophores in modern drug…
Ecumicin is a novel anti-tuberculosis agent produced by Nonomuraea sp. MJM5123 as a new strain of actinomycetes. First, in order…