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The Essential Medicinal Chemistry of Curcumin
- Kathryn M. Nelson, Jayme L. Dahlin, J. Bisson, J. Graham, G. Pauli, M. Walters
- BiologyJournal of Medicinal Chemistry
- 11 January 2017
Evidence is provided that curcumin is an unstable, reactive, nonbioavailable compound and, therefore, a highly improbable lead and, on the basis of this in-depth evaluation, potential new directions for research onCurcuminoids are discussed.
Dentin biomodification: strategies, renewable resources and clinical applications.
The pharmacognosy of Humulus lupulus L. (hops) with an emphasis on estrogenic properties.
Low-Oxygen-Recovery Assay for High-Throughput Screening of Compounds against Nonreplicating Mycobacterium tuberculosis
- Sang-Hyun Cho, S. Warit, B. Wan, C. Hwang, G. Pauli, S. Franzblau
- BiologyAntimicrobial Agents and Chemotherapy
- 8 January 2007
This high-throughput, luminescence-based low-oxygen-recovery assay (LORA) was developed to screen antimicrobial agents against NRP Mycobacterium tuberculosis and is sufficiently robust for use for primary high- throughput screening of compounds against N RP M. tuberculosis.
Quantitative 1H NMR: development and potential of a method for natural products analysis.
Based on a brief revision of what constitutes state-of-the-art "quantitative experimental conditions" for (1)H quantitative NMR (qHNMR), this comprehensive review contains almost 200 references and…
IDENTIFICATION OF HUMAN HEPATIC CYTOCHROME P450 ENZYMES INVOLVED IN THE METABOLISM OF 8-PRENYLNARINGENIN AND ISOXANTHOHUMOL FROM HOPS (HUMULUS LUPULUS L.)
- Jian Guo, D. Nikolić, L. Chadwick, G. Pauli, R. V. van Breemen
- BiologyDrug Metabolism And Disposition
- 1 July 2006
The results suggest that the estrogenicity of hop constituents in vivo will depend in part on metabolic conversion that may show individual variation.
Phytochemistry and biological properties of glabridin.
Universal quantitative NMR analysis of complex natural samples.
Metabolism of xanthohumol and isoxanthohumol, prenylated flavonoids from hops (Humulus lupulus L.), by human liver microsomes.
- D. Nikolić, Yongmei Li, L. Chadwick, G. Pauli, R. V. van Breemen
- Chemistry, BiologyJournal of Mass Spectrometry
- 1 March 2005
Since XN can be converted to IX through acid-catalyzed cyclization in the stomach, XN might contribute to the in vivo levels of estrogenic 8-PN following consumption of hops extracts.
Safety and efficacy of black cohosh and red clover for the management of vasomotor symptoms: a randomized controlled trial
Black cohosh and red clover did not significantly reduce the frequency of vasomotor symptoms as compared with placebo and safety monitoring indicated that both botanicals were safe as administered.