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dynemicin A

An enediyne antineoplastic antibiotic hybrid containing an anthraquinone moiety isolated from the bacterium Micromonospora chersina. The… 
National Institutes of Health

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4 relations

Broader (4)

AnthraquinonesAnti-Bacterial AgentsAntibiotics, AntineoplasticEnediynes

Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
2008
2008
Thebiosyntheticgenes encoding for theproductionofthe dynemicin enediyne core inMicromonospora chersina ATCC 53710
Dynemicin is a novel anthraquinone-fused member of the 10-membered enediyne antitumor antibiotic family. The development of a… 
2005
2005
Docking, triggering, and biological activity of dynemicin A in DNA: a computational study.
The triggering and biological activity of the naturally occurring enediyne dynemicin A (1) was investigated, both inside and… 
1997
1997
Synthesis and biological evaluation of novel cyclic enediyne compounds related to dynemicin A as antitumor agents.
Novel cyclic enediyne compounds, which are simple functional analogs of dynemicin A (1) having the bicyclo-[7.3.1]tridec-4-ene-2… 
1997
1997
Selective cleavages of tRNAPhe with secondary and tertiary structures by enediyne antitumor antibiotics.
1997
1997
Structure-activity relationships of cyclic enediynes related to dynemicin A. I. Synthesis and antitumor activity of 9-acetoxy enediynes equipped with aryl carbamate moieties.
A series of the 9-acetoxy enediyne compounds, 6a-k which were simplified from natural dynemicin A, and designed to be equipped… 
1995
1995
Sequence preference for strand cleavage of gapped duplexes by dynemicin A: possible mechanism of sequence-dependent double-stranded breaks.
A double-stranded DNA cleavage mechanism by a novel enediyne type antitumor antibiotic, dynemicin A, has been investigated… 
1993
1993
DNA binding and cleavage of a novel antitumor antibiotic dynemicin A: detection of binding and cleavage sites by exonuclease III digestion and alkali-induced cutting reactions.
We found here that dynemicin A effectively breaks DNA strands under alkaline pH condition. Binding of dynemicin A to double… 
1992
1992
C-1' hydrogen abstraction of deoxyribose in DNA strand scission by dynemicin A.
1991
1991
Studies on DNA-cleaving agents: computer modeling analysis of the mechanism of activation and cleavage of dynemicin-oligonucleotide complexes.
Dynemicin A is a recently identified antitumor antibiotic. Upon activation, dynemicin is reported to cause double-stranded… 
Highly Cited
1990
Highly Cited
1990
Visible light induced DNA cleavage by the hybrid antitumor antibiotic dynemicin A.
Dynemicin A, which is a hybrid antitumor antibiotic containing anthraquinone and enediyne cores, effectively breaks DNA strands… 
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