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doxifluridine

Known as: 5-DFUR, doxyfluridine, 5'-DFUR 
A fluoropyrimidine derivative and oral prodrug of the antineoplastic agent 5-fluorouracil (5-FU) with antitumor activity. Doxifluridine, designed to… 
National Institutes of Health

Related topics

Related topics

6 relations

Broader (4)

Antimetabolites, AntineoplasticAppetite StimulantsFloxuridineImmunosuppressive Agents

Narrower (1)

Furtulon
NCIt Antineoplastic Agent Terminology

Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
Highly Cited
2011
Highly Cited
2011
Prognostic Significance of miR-181b and miR-21 in Gastric Cancer Patients Treated with S-1/Oxaliplatin or Doxifluridine/Oxaliplatin
Background The goal of this study is to evaluate the effectiveness of S-1/Oxaliplatin vs. Doxifluridine/Oxaliplatin regimen and… 
Highly Cited
2008
Highly Cited
2008
Heterogeneous Ribonucleoprotein K and Thymidine Phosphorylase Are Independent Prognostic and Therapeutic Markers for Nasopharyngeal Carcinoma
Purpose: Heterogeneous ribonucleoprotein K (hnRNP K) regulates thymidine phosphorylase (TP) mRNA stability. The aim of the… 
Highly Cited
2003
Highly Cited
2003
Liquid chromatography-mass spectrometry method for the analysis of the anti-cancer agent capecitabine and its nucleoside metabolites in human plasma.
  • Yan XuJ. Grem
  • Journal of chromatography. B, Analytical…
  • 2003
  • Corpus ID: 11067481
Highly Cited
2002
Highly Cited
2002
Uridine phosphorylase (-/-) murine embryonic stem cells clarify the key role of this enzyme in the regulation of the pyrimidine salvage pathway and in the activation of fluoropyrimidines.
We have reported the elevation of uridine phosphorylase (UPase) in many solid tumors and the presence of a variant phosphorolytic… 
2002
2002
Population Pharmacokinetic Analysis of the Major Metabolites of Capecitabine
Capecitabine has been developed as an orally administered tumor selective fluoropyrimidine for use in the treatment of breast and… 
1997
1997
Thymidine phosphorylase activity in human bladder cancer: difference between superficial and invasive cancer.
The activity of thymidine phosphorylase (TdR-Pase), which is identical to platelet-derived endothelial cell growth factor (a… 
Highly Cited
1990
Highly Cited
1990
Anticachectic activity of 5'-deoxy-5-fluorouridine in a murine tumor cachexia model, colon 26 adenocarcinoma.
Murine colon 26 adenocarcinoma causes a progressive weight loss and physiological changes associated with cachexia when it grows… 
Highly Cited
1981
Highly Cited
1981
Selective activation of 5'-deoxy-5-fluorouridine by tumor cells as a basis for an improved therapeutic index.
The intracellular metabolism of a new fluoropyrimidine, 5'-deoxy-5-fluorouridine (5'-dFUrd), was compared with the metabolism of… 
Highly Cited
1980
Highly Cited
1980
Metabolism and biological activity of 5'-deoxy-5-fluorouridine, a novel fluoropyrimidine.
5'-Deoxy-5-fluorouridine (5'-dFUrd; Roche 21-9738) is a recently synthesized antineoplastic agent with therapeutic potential. The… 
1980
1980
Tissue distribution of 5'-deoxy-5-fluorouridine and derived 5-fluorouracil in tumor-bearing mice and rats.
Distribution of 5-fluorouracil (5-FU) in various tissues including transplanted tumors was examined 1, 3 (or 4), and 24 hr after… 
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