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doxifluridine

Known as: 5-DFUR, doxyfluridine, 5'-DFUR 
A fluoropyrimidine derivative and oral prodrug of the antineoplastic agent 5-fluorouracil (5-FU) with antitumor activity. Doxifluridine, designed to… 
National Institutes of Health

Related topics

Related topics

6 relations

Broader (4)

Antimetabolites, AntineoplasticAppetite StimulantsFloxuridineImmunosuppressive Agents

Narrower (1)

Furtulon
NCIt Antineoplastic Agent Terminology

Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
Highly Cited
2014
Highly Cited
2014
Mitochondrial induced and self-monitored intrinsic apoptosis by antitumor theranostic prodrug: in vivo imaging and precise cancer treatment.
Activation of apoptosis, the cell death machinery, in tumor cells by organelle-specific delivery of antitumor theranostic agent… 
Highly Cited
2004
Highly Cited
2004
Cytokines induce thymidine phosphorylase expression in tumor cells and make them more susceptible to 5′-deoxy-5-fluorouridine
The present study shows that various cytokines such as tumor necrosis factor (TNFα), interleukin-1α (IL-1α), and interferon… 
Highly Cited
2002
Highly Cited
2002
Immunohistochemical variation of human equilibrative nucleoside transporter 1 protein in primary breast cancers.
Gemcitabine and capecitabine are nucleoside analogues used in chemotherapy strategies for the treatment of breast cancer. We… 
Highly Cited
2002
Highly Cited
2002
Effect of renal impairment on the pharmacokinetics and tolerability of capecitabine (Xeloda) in cancer patients
Abstract.Purpose: The primary objective of this study was to investigate the influence of renal impairment on the… 
Highly Cited
1999
Highly Cited
1999
Effect of hepatic dysfunction due to liver metastases on the pharmacokinetics of capecitabine and its metabolites.
Capecitabine (Xeloda) is a rationally designed oral, tumor-selective fluoropyrimidine carbamate aimed at preferential conversion… 
Highly Cited
1998
Highly Cited
1998
Tumor selective delivery of 5-fluorouracil by capecitabine, a new oral fluoropyrimidine carbamate, in human cancer xenografts.
Highly Cited
1998
Highly Cited
1998
Positive correlation between the efficacy of capecitabine and doxifluridine and the ratio of thymidine phosphorylase to dihydropyrimidine dehydrogenase activities in tumors in human cancer xenografts…
Capecitabine (N4-pentyloxycarbonyl-5'-deoxy-5-fluorocytidine) is a new fluoropyrimidine carbamate, which is converted to 5… 
Highly Cited
1995
Highly Cited
1995
Increased sensitivity to the prodrug 5'-deoxy-5-fluorouridine and modulation of 5-fluoro-2'-deoxyuridine sensitivity in MCF-7 cells transfected with thymidine phosphorylase.
Platelet-derived endothelial cell growth factor (PD-ECGF) is identical to human thymidine phosphorylase (dThdPase). The human MCF… 
Highly Cited
1986
Highly Cited
1986
Sensitivity of human, murine, and rat cells to 5-fluorouracil and 5'-deoxy-5-fluorouridine in relation to drug-metabolizing enzymes.
Six cell lines differing in histological origin were studied regarding the growth inhibitory effect of fluoropyrimidines in… 
Highly Cited
1980
Highly Cited
1980
Metabolism and biological activity of 5'-deoxy-5-fluorouridine, a novel fluoropyrimidine.
5'-Deoxy-5-fluorouridine (5'-dFUrd; Roche 21-9738) is a recently synthesized antineoplastic agent with therapeutic potential. The… 
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