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dopamine-beta-monooxygenase activity

Known as: dopamine-B-hydroxylase activity, 3,4-dihydroxyphenethylamine beta-oxidase activity, dopamine beta-hydroxylase activity 
Catalysis of the reaction: L-ascorbate + dopamine + O(2) = (R)-noradrenaline + dehydroascorbate + H(2)O. [EC:1.14.17.1, RHEA:19120]
National Institutes of Health

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Dopamine-beta-monooxygenase

Papers overview

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Highly Cited
2005
Highly Cited
2005
Imidazo[1,5-a]pyridine: a versatile architecture for stable N-heterocyclic carbenes.
The imidazo[1,5-a]pyridine skeleton provides a versatile platform for the generation of new types of stable N-heterocyclic… Expand
Highly Cited
2001
Highly Cited
2001
A quantitative-trait analysis of human plasma-dopamine beta-hydroxylase activity: evidence for a major functional polymorphism at the DBH locus.
Dopamine-beta-hydroxylase (D beta H) catalyzes the conversion of dopamine to norepinephrine and is released from sympathetic… Expand
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Highly Cited
1989
Highly Cited
1989
Regional brain abnormalities in norepinephrine uptake and dopamine beta-hydroxylase activity in the genetically epilepsy-prone rat.
Two markers for noradrenergic neurons: 1) desmethylimipramine sensitive norepinephrine (NE) uptake and 2) dopamine beta… Expand
1986
1986
Ascorbic acid specifically enhances dopamine beta-monooxygenase activity in resting and stimulated chromaffin cells.
  • M. Levine
  • The Journal of biological chemistry
  • 1986
    • Corpus ID: 24163908
Ascorbic acid enhancement of norepinephrine formation from tyrosine in cultured bovine chromaffin cells was characterized in… Expand
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Highly Cited
1986
Highly Cited
1986
Role of ascorbic acid in dopamine beta-hydroxylation. The endogenous enzyme cofactor and putative electron donor for cofactor regeneration.
The role(s) of ascorbic acid in dopamine beta-hydroxylation was studied in primary cultures of bovine adrenomedullary chromaffin… Expand
Highly Cited
1982
Highly Cited
1982
Opioid peptides and noradrenaline co-exist in large dense-cored vesicles from sympathetic nerve
The possibility that opioid peptides and noradrenaline co-exist not only in the desheathed bundle of bovine splenic nerve which… Expand
Highly Cited
1981
Highly Cited
1981
The applicability of 500-MHz high-resolution 1H-NMR spectroscopy for the structure determination of carbohydrates derived from glycoproteins
This report describes the application of 500-MHz 1H-NMR spectroscopy for the determination of the primary structures of the… Expand
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Highly Cited
1977
Highly Cited
1977
Plasma noradrenaline concentrations in experimental renovascular hypertension in the rat.
1. Plasma noradrenaline concentrations and dopamine beta-hydroxylase activity have been measured at various stages in the… Expand
Highly Cited
1976
Highly Cited
1976
Vascular and brain dopamine beta-hydroxylase activity in young spontaneously hypertensive rats.
Dopamine beta-hydroxylase activity was higher in mesenteric vessels, adrenal glands, and serum of 3-week-old spontaneously… Expand
Highly Cited
1972
Highly Cited
1972
Membrane proteins of chromaffin granules, dopamine -hydroxylase, a major constituent.
1. Soluble lysates and membranes were prepared from chromaffin granules isolated from bovine adrenal medulla. The detergent N… Expand
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