donepezil

Known as: DONEP, Donepezilum, donepezil [Chemical/Ingredient] 
The hydrochloride salt of a piperidine derivative with neurocognitive-enhancing activity. Donepezil reversibly inhibits acetylcholinesterase, thereby… (More)

Topic mentions per year

Topic mentions per year

1986-2018
010020019862018

Papers overview

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Highly Cited
2012
Highly Cited
2012
BACKGROUND Clinical trials have shown the benefits of cholinesterase inhibitors for the treatment of mild-to-moderate Alzheimer's… (More)
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Highly Cited
2006
Highly Cited
2006
BACKGROUND The cholinesterase inhibitor donepezil is used to treat mild-to-moderate Alzheimer's disease. Its efficacy in severe… (More)
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Highly Cited
2005
Highly Cited
2005
BACKGROUND Mild cognitive impairment is a transitional state between the cognitive changes of normal aging and early Alzheimer's… (More)
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Highly Cited
2004
Highly Cited
2004
CONTEXT Memantine is a low- to moderate-affinity, uncompetitive N-methyl-D-aspartate receptor antagonist. Controlled trials have… (More)
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Highly Cited
2004
Highly Cited
2004
BACKGROUND Cholinesterase inhibitors produce small improvements in cognitive and global assessments in Alzheimer's disease. We… (More)
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Highly Cited
2001
Highly Cited
2001
OBJECTIVE To evaluate the long-term clinical efficacy and safety of donepezil versus placebo over 1 year in patients with mild to… (More)
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Highly Cited
2001
Highly Cited
2001
OBJECTIVE To investigate the efficacy and safety of donepezil in patients with moderate to severe AD (standardized Mini-Mental… (More)
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Highly Cited
2001
Highly Cited
2001
OBJECTIVE To examine the effects of donepezil compared with placebo on the preservation of function in patients with AD over a 1… (More)
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Highly Cited
1998
Highly Cited
1998
The efficacy and safety of donepezil as a treatment for patients with mild to moderate Alzheimer's disease (AD) was investigated… (More)
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Highly Cited
1998
Highly Cited
1998
BACKGROUND Donepezil hydrochloride (Aricept) is a selective acetylcholinesterase inhibitor developed for the treatment of… (More)
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