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Donepezil hydrochloride

Known as: 1-Benzyl-4-((5,6-dimethoxy-1-indanon)-2-yl)methylpiperidine Hydrochloride, donepezil hcl 
The hydrochloride salt of a piperidine derivative with neurocognitive-enhancing activity. Donepezil reversibly inhibits acetylcholinesterase, thereby… 
National Institutes of Health

Related topics

Related topics

9 relations
Alzheimer's DiseaseCytochrome P450 2D6, humanDonepezil hydrochloride 10 MG Oral TabletDonepezil hydrochloride 5 MG Disintegrating Oral Tablet [Aricept]

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AriceptNamzaric

Papers overview

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Highly Cited
2008
Highly Cited
2008
In vivo visualization of donepezil binding in the brain of patients with Alzheimer's disease.
WHAT IS ALREADY KNOWN ABOUT THIS SUBJECT * Deficit in central cholinergic neurotransmission is a consistent change associated… 
2006
2006
SPECT Follow‐Up Study of Cerebral Blood Flow Changes During Donepezil Therapy in Patients with Alzheimer's Disease
Background and Purpose. Treatment with acetylcholinesterase inhibitors (AchEIs) is beneficial for patients with Alzheimer's… 
2006
2006
Acetylcholinesterase inhibitor acting on the brain improves detrusor overactivity caused by cerebral infarction in rats
2004
2004
Concurrent administration of donepezil HCl and levodopa/carbidopa in patients with Parkinson's disease: assessment of pharmacokinetic changes and safety following multiple oral doses.
AIM The use of acetylcholinesterase inhibitors for the treatment of comorbid Alzheimer's disease in Parkinson's disease (PD… 
2003
2003
Acetylcholinesterase Inhibitor (Donepezil Hydrochloride) Reduces Heart Rate Variability
Summary: An acetylcholinesterase inhibitor (donepezil hydrochloride) has recently been used for the treatment of senile dementia… 
Highly Cited
2002
Highly Cited
2002
Concurrent administration of donepezil HCl and ketoconazole: assessment of pharmacokinetic changes following single and multiple doses.
AIM The aim of this study was to examine the pharmacokinetics of donepezil HCl and ketoconazole separately, and in combination… 
Highly Cited
1998
Highly Cited
1998
Concurrent administration of donepezil HCl and cimetidine: assessment of pharmacokinetic changes following single and multiple doses.
AIM The aim of this study was to examine the pharmacokinetics of donepezil HCl and cimetidine separately, and in combination… 
1998
1998
Concurrent administration of donepezil HCl and theophylline: assessment of pharmacokinetic changes following multiple-dose administration in healthy volunteers.
AIM The aim of the study was to evaluate the pharmacokinetics of theophylline administered alone, and in combination with… 
1998
1998
An evaluation of the pharmacokinetics of donepezil HCl in patients with impaired hepatic function.
AIM The aim of this study was to evaluate the pharmacokinetic profile of donepezil HCl (5 mg) in patients with impaired hepatic… 
1998
1998
Concurrent administration of donepezil HCl and digoxin: assessment of pharmacokinetic changes.
AIM The aim of this study was to examine the pharmacokinetics of donepezil HCl and digoxin separately, and in combination… 
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