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Donepezil hydrochloride

Known as: 1-Benzyl-4-((5,6-dimethoxy-1-indanon)-2-yl)methylpiperidine Hydrochloride, donepezil hcl 
The hydrochloride salt of a piperidine derivative with neurocognitive-enhancing activity. Donepezil reversibly inhibits acetylcholinesterase, thereby… 
National Institutes of Health

Related topics

Related topics

9 relations
Alzheimer's DiseaseCytochrome P450 2D6, humanDonepezil hydrochloride 10 MG Oral TabletDonepezil hydrochloride 5 MG Disintegrating Oral Tablet [Aricept]

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AriceptNamzaric

Papers overview

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Highly Cited
2012
Highly Cited
2012
Donepezil in Parkinson's disease dementia: A randomized, double‐blind efficacy and safety study
Parkinson's disease dementia (PDD) is associated with cholinergic deficits. This report presents an efficacy and safety study of… 
Highly Cited
2010
Highly Cited
2010
Electrospun water soluble polymer mat for ultrafast release of Donepezil HCl
Electrostatic spinning (Electrospinning, ES) was applied to prepare Donepezil HCl loaded nanofibers as a poten- tial orally… 
Highly Cited
2007
Highly Cited
2007
A randomized, double‐blind, placebo‐controlled trial of donepezil hydrochloride (Aricept) for reducing the incidence of postoperative delirium after elective total hip replacement
This was a pilot, phase 2a study to assess methodological feasibility and the safety and efficacy of donepezil in preventing… 
Highly Cited
2005
Highly Cited
2005
Donepezil for dementia in Parkinson’s disease: a randomised, double blind, placebo controlled, crossover study
Objective: To study the safety and efficacy of a cholinesterase inhibitor, donepezil hydrochloride, for the treatment of dementia… 
Highly Cited
2005
Highly Cited
2005
Does donepezil treatment slow the progression of hippocampal atrophy in patients with Alzheimer's disease?
OBJECTIVE The only approved pharmacological approach for the symptomatic treatment of Alzheimer's disease in Japan is the use of… 
Highly Cited
2003
Highly Cited
2003
Donepezil HCl (E2020) maintains functional brain activity in patients with Alzheimer disease: results of a 24-week, double-blind, placebo-controlled study.
OBJECTIVE The authors evaluated the effects of donepezil (10 mg/day) versus placebo on brain glucose metabolism. METHODS This… 
Review
2002
Review
2002
Research and development of donepezil hydrochloride, a new type of acetylcholinesterase inhibitor.
A wide range of evidence shows that cholinesterase (ChE) inhibitors can interfere with the progression of Alzheimer's disease (AD… 
Review
2000
Review
2000
Donepezil hydrochloride (E2020) and other acetylcholinesterase inhibitors.
A wide range of evidence shows that acetylcholinesterase (AChE) inhibitors can interfere with the progression of Alzheimer's… 
Highly Cited
2000
Highly Cited
2000
A 12-week, open trial of donepezil hydrochloride in patients with multiple sclerosis and associated cognitive impairments.
Cognitive dysfunction occurs in up to 65% of patients with multiple sclerosis (MS), but there is no effective treatment for the… 
Highly Cited
1998
Highly Cited
1998
Donepezil improves cognition and global function in Alzheimer disease: a 15-week, double-blind, placebo-controlled study. Donepezil Study Group.
BACKGROUND Donepezil hydrochloride (Aricept) is a selective acetylcholinesterase inhibitor developed for the treatment of… 
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