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E 2020

Known as: E-2020, E2020 
National Institutes of Health

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donepezil

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2015
2015
Molecular conformation , intermolecular interaction and the electrostatic properties of Donepezil molecule in the active site of AChE : A molecular docking and charge density analysis 8 . 1
  • 2015
  • Corpus ID: 59484716
One of the currently available allopathic drugs for AD is donepezil, (R,S)-1-benzyl4-[(5,6-dimethoxy-1-indanon)-2-yl… 
2013
2013
Template-Based de Novo Design for Type II Kinase Inhibitors and Its Extended Application to Acetylcholinesterase Inhibitors
There is a compelling need to discover type II inhibitors targeting the unique DFG-out inactive kinase conformation since they… 
2011
2011
AC 2011-1499: INTRODUCING SYSTEMS THINKING TO THE ENGI- NEER OF 2020
To prepare the engineer of 2020 to address the grand challenges of engineering, the E2020 Scholars Program at Iowa State… 
2004
2004
Modulation of NM DA receptor by huperzine A in rat cerebral cortex
AB :To investigate山e efects of huperzine A 【Hup A)on NMDA receptors in rat cerebral coAex. ~IIITItODS:1)The efect ofhup A on NMDA… 
2003
2003
Effects of huperzine A and E2020 on learning and memory related gene expression in hippocampus of senescence-accelerate mice
2003
2003
Effects of E2020 on learning and memory behaviors and brain monamine and amino acid neurotransmitters in sencescence-accelerated mice
1998
1998
Quaternary-Lipophilic Carbamates with Blood Brain Barrier Permeability as Potential Drugs for the Treatment of Diseases Associated with Cholinergic Deficiency
Cholinergic deficiency in the central nervous system may be associated with cognitive impairment (1–3). In pathological… 
1997
1997
Cognition Enhancing Profile of CR 2249, a New NMDA‐Glycine Site Modulator
Memory processes have been widely studied in recent decades. Unfortunately, although several intriguing hypotheses about the… 
1996
1996
Impressive results with donepezil in Alzheimer’s disease
A pivotal phase III trial of the selective cholinesterase inhibitor donepezil [E-2020; Eisai] has shown that the drug… 
1992
1992
The pharmacokinetics pk and pharmacodynamics pd of e2020 r s 1 benzyl 4 5 6 dimethoxy 1 indanon 2 ylmethylpiperdine hydrochloride a novel inhibitor of acetylcholinesterase ache implications for use…