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- Publications
- Influence
Tumor cells require thymidylate kinase to prevent dUTP incorporation during DNA repair.
- Chun-Mei Hu, M. Yeh, +10 authors Z. Chang
- Biology, Medicine
- Cancer cell
- 10 July 2012
The synthesis of dTDP is unique because there is a requirement for thymidylate kinase (TMPK). All other dNDPs including dUDP are directly produced by ribonucleotide reductase (RNR). We report the… Expand
Protocadherin 10 suppresses tumorigenesis and metastasis in colorectal cancer and its genetic loss predicts adverse prognosis
- Tzu-Ming Jao, Ming-Hong Tsai, +8 authors Ya-Chien Yang
- Biology, Medicine
- International journal of cancer
- 1 December 2014
Protocadherin 10 (PCDH10), a novel tumor suppressor gene in human cancers, is located in a common deleted region at chromosome 4q28 in colorectal cancer (CRC). This study aimed to ascertain the… Expand
Oversampling to Overcome Overfitting: Exploring the Relationship between Data Set Composition, Molecular Descriptors, and Predictive Modeling Methods
- Chia-Yun Chang, M. Hsu, E. X. Esposito, Y. Tseng
- Computer Science, Medicine
- J. Chem. Inf. Model.
- 15 March 2013
TLDR
Design of accurate predictors for DNA-binding sites in proteins using hybrid SVM-PSSM method
- S. Ho, Fu-Chieh Yu, Chia-Yun Chang, Hui-Ling Huang
- Computer Science, Medicine
- Biosyst.
- 1 July 2007
TLDR
Random-Coil Behavior of Chemically Denatured Topologically Knotted Proteins Revealed by Small-Angle X-ray Scattering.
- Po-Min Shih, Iren Wang, +7 authors S. Hsu
- Chemistry, Medicine
- The journal of physical chemistry. B
- 21 April 2015
Recent studies on the mechanisms by which topologically knotted proteins attain their natively knotted structures have intrigued theoretical and experimental biophysicists. Of particular interest is… Expand
Entropic stabilization of a deubiquitinase provides conformational plasticity and slow unfolding kinetics beneficial for functioning on the proteasome
- Y. Lee, Chia-Yun Chang, S. Chen, Yun-Ru Pan, M. Ho, S. Hsu
- Chemistry, Medicine
- Scientific reports
- 24 March 2017
Human ubiquitin C-terminal hydrolyase UCH-L5 is a topologically knotted deubiquitinase that is activated upon binding to the proteasome subunit Rpn13. The length of its intrinsically disordered… Expand
Forensic Application of Analytical Mechanics in Fatal Fall From a Height
- Wu-ting Tsai, Chia-Yun Chang, C. Hu
- Psychology, Medicine
- Journal of forensic sciences
- 1 July 2019
Fatal fall from a height initiated with a swinging motion on the sagittal plane of the victim's body is examined. Method of analytical mechanics is adopted to establish the functional relations… Expand
Microwave Assisted Reduction of Pt-Catalyst by N-Phenyl-p-Phenylenediamine for Proton Exchange Membrane Fuel Cells
- Ming-Jer Tsai, Tar-Hwa Hsieh, Y. Wang, K. Ho, Chia-Yun Chang
- Chemistry, Medicine
- Polymers
- 1 March 2017
The presence of N-phenyl-p-phenylenediamine (PPDA: a dimer of aniline) during microwave (MW) irradiation can significantly improve Pt-loading on the XC72 carbon matrix as a catalyst support of proton… Expand
Preparation and characterization of DNA-aromatic surfactant complexes for optoelectronic applications
- Tingyu Lin, Chia-Yun Chang, +5 authors Yu-Chueh Hung
- Materials Science, Engineering
- OPTO
- 10 February 2011
DNA biopolymer has emerging as a promising material in photonic applications. In this paper, we present the preparation and characterization of a series of DNA-surfactant complexes based on aromatic… Expand
Template-Based de Novo Design for Type II Kinase Inhibitors and Its Extended Application to Acetylcholinesterase Inhibitors
- Bo-Han Su, Yi-Syuan Huang, Chia-Yun Chang, Yi-shu Tu, Y. Tseng
- Biology, Medicine
- Molecules
- 31 October 2013
There is a compelling need to discover type II inhibitors targeting the unique DFG-out inactive kinase conformation since they are likely to possess greater potency and selectivity relative to… Expand