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The synthesis of dTDP is unique because there is a requirement for thymidylate kinase (TMPK). All other dNDPs including dUDP are directly produced by ribonucleotide reductase (RNR). We report the… Continue Reading
Protocadherin 10 (PCDH10), a novel tumor suppressor gene in human cancers, is located in a common deleted region at chromosome 4q28 in colorectal cancer (CRC). This study aimed to ascertain the… Continue Reading
In this paper, we investigate the design of accurate predictors for DNA-binding sites in proteins from amino acid sequences. As a result, we propose a hybrid method using support vector machine (SVM)… Continue Reading
Recent studies on the mechanisms by which topologically knotted proteins attain their natively knotted structures have intrigued theoretical and experimental biophysicists. Of particular interest is… Continue Reading
The traditional biological assay is very time-consuming, and thus the ability to quickly screen large numbers of compounds against a specific biological target is appealing. To speed up the… Continue Reading
Human ubiquitin C-terminal hydrolyase UCH-L5 is a topologically knotted deubiquitinase that is activated upon binding to the proteasome subunit Rpn13. The length of its intrinsically disordered… Continue Reading
DNA biopolymer has emerging as a promising material in photonic applications. In this paper, we present the preparation and characterization of a series of DNA-surfactant complexes based on aromatic… Continue Reading
The presence of N-phenyl-p-phenylenediamine (PPDA: a dimer of aniline) during microwave (MW) irradiation can significantly improve Pt-loading on the XC72 carbon matrix as a catalyst support of proton… Continue Reading
There is a compelling need to discover type II inhibitors targeting the unique DFG-out inactive kinase conformation since they are likely to possess greater potency and selectivity relative to… Continue Reading
This study aims to analyze DNA-binding proteins via acquisition of interpretable knowledge which can accurately predict binding sites in proteins to understand DNA-protein recognition mechanism. For… Continue Reading