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disoxaril

Known as: 5-(7-(4-(4,5-dihydro-2-oxazolyl)phenoxy)heptyl)-3-methylisoxazole 
A compound with activity against human picornaviruses. Disoxaril binds to the hydrophobic pocket within the viral VP1 capsid protein and prevents… 
National Institutes of Health

Papers overview

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Review
1995
Review
1995
This chapter reviews the two most common central nervous system (CNS) enterovirus (EV) infections, meningitis and encephalitis… 
1995
1995
The effects of enviroxime, disoxaril and ribavirin in pair combinations on poliovirus type 1 (Mahoney) replication in FL cells… 
Highly Cited
1994
Highly Cited
1994
A series of 1,2,4-oxadiazoles has been prepared as ester bioisosteres and tested against 15 human rhinovirus serotypes, and the… 
1992
1992
A series of conformationally restricted analogs of disoxaril has been synthesized and evaluated against human rhinovirus types… 
1991
1991
The binding affinities (Kds) and the rates of association and dissociation of members of a chemical class of antiviral compounds… 
1990
1990
Disoxaril (5-[7-[4(4,5-dihydro-2-oxazolyl)phenoxy]-heptyl]-3- methylisoxazole) protects poliovirus procapsids against alkaline… 
1989
1989
A number of 2,6-disubstituted analogues of disoxaril, a broad spectrum antipicornavirus agent, have been prepared and evaluated… 
1989
1989
Enteroviruses can cause persistent central nervous system (CNS) infections in agammaglobulinemic individuals. Because these… 
1988
1988
X-ray crystallography studies of racemic 5-[7-[4-(4,5-dihydro-4-methyl-2-oxazolyl)phenoxy]heptyl]- 3-methylisoxazole bound to…