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disoxaril

Known as: 5-(7-(4-(4,5-dihydro-2-oxazolyl)phenoxy)heptyl)-3-methylisoxazole 
A compound with activity against human picornaviruses. Disoxaril binds to the hydrophobic pocket within the viral VP1 capsid protein and prevents… 
National Institutes of Health

Related topics

Related topics

3 relations

Broader (2)

Antiviral AgentsIsoxazoles

Narrower (1)

Win 51711

Papers overview

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1999
1999
Cytotoxicity of the synergistic antienteroviral combination of enviroxime and disoxaril.
When combined, enviroxime and disoxaril, two selective picornavirus inhibitors, exert a marked synergistic inhibitory effect on… 
1995
1995
Synergistic inhibitory effect of enviroxime and disoxaril on poliovirus type 1 replication.
The effects of enviroxime, disoxaril and ribavirin in pair combinations on poliovirus type 1 (Mahoney) replication in FL cells… 
Highly Cited
1994
Highly Cited
1994
Oxadiazoles as ester bioisosteric replacements in compounds related to disoxaril. Antirhinovirus activity.
A series of 1,2,4-oxadiazoles has been prepared as ester bioisosteres and tested against 15 human rhinovirus serotypes, and the… 
1992
1992
Conformationally restricted analogues of disoxaril: a comparison of the activity against human rhinovirus types 14 and 1A.
A series of conformationally restricted analogs of disoxaril has been synthesized and evaluated against human rhinovirus types… 
1992
1992
CoMFA analysis of the interactions of antipicornavirus compounds in the binding pocket of human rhinovirus-14.
A CoMFA analysis of eight compounds related to disoxaril whose X-ray structures bound to HRV-14 had been determined resulted in a… 
1991
1991
Binding affinities of structurally related human rhinovirus capsid-binding compounds are related to their activities against human rhinovirus type 14
The binding affinities (Kds) and the rates of association and dissociation of members of a chemical class of antiviral compounds… 
1990
1990
Disoxaril stabilization and immunogenicity of poliovirus procapsids.
Disoxaril (5-[7-[4(4,5-dihydro-2-oxazolyl)phenoxy]-heptyl]-3- methylisoxazole) protects poliovirus procapsids against alkaline… 
1989
1989
Clearance of a persistent human enterovirus infection of the mouse central nervous system by the antiviral agent disoxaril.
Enteroviruses can cause persistent central nervous system (CNS) infections in agammaglobulinemic individuals. Because these… 
1989
1989
Synthesis and structure-activity studies of some disubstituted phenylisoxazoles against human picornavirus.
A number of 2,6-disubstituted analogues of disoxaril, a broad spectrum antipicornavirus agent, have been prepared and evaluated… 
1988
1988
Enantiomeric effects of homologues of disoxaril on the inhibitory activity against human rhinovirus-14.
X-ray crystallography studies of racemic 5-[7-[4-(4,5-dihydro-4-methyl-2-oxazolyl)phenoxy]heptyl]- 3-methylisoxazole bound to… 
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