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disoxaril

Known as: 5-(7-(4-(4,5-dihydro-2-oxazolyl)phenoxy)heptyl)-3-methylisoxazole 
A compound with activity against human picornaviruses. Disoxaril binds to the hydrophobic pocket within the viral VP1 capsid protein and prevents… Expand
National Institutes of Health

Papers overview

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2006
2006
In this work we evaluated the ability of 2,6-di-O-methyl-beta-cyclodextrin (DM-beta-Cyd) to include the anti-rhinovirus drug… Expand
Review
1995
Review
1995
This chapter reviews the two most common central nervous system (CNS) enterovirus (EV) infections, meningitis and encephalitis… Expand
Highly Cited
1994
Highly Cited
1994
A series of 1,2,4-oxadiazoles has been prepared as ester bioisosteres and tested against 15 human rhinovirus serotypes, and the… Expand
1993
1993
A series of tetrazole analogues of Win 54954, a broad-spectrum antipicornavirus compound, has been synthesized to address the… Expand
1992
1992
A series of conformationally restricted analogs of disoxaril has been synthesized and evaluated against human rhinovirus types… Expand
1991
1991
14 S subunits of poliovirus at 37 degrees undergo a rapid thermodenaturation, whereby all neutralizing epitopes are lost. This… Expand
1990
1990
Disoxaril (5-[7-[4(4,5-dihydro-2-oxazolyl)phenoxy]-heptyl]-3- methylisoxazole) protects poliovirus procapsids against alkaline… Expand
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1989
1989
A number of 2,6-disubstituted analogues of disoxaril, a broad spectrum antipicornavirus agent, have been prepared and evaluated… Expand
1989
1989
Enteroviruses can cause persistent central nervous system (CNS) infections in agammaglobulinemic individuals. Because these… Expand
Highly Cited
1987
Highly Cited
1987
Disoxaril [WIN 51711, 5-[7-[4(4,5-dihydro-2-oxazolyl)phenoxy]heptyl]-3- methylisoxazole] inhibits the replication of polioviruses… Expand