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Virucidal activity of a new hand disinfectant with reduced ethanol content: comparison with other alcohol-based formulations
A new formula with reduced ethanol content in combination with 10% propan-1-ol, 5.3-diol and 0.7% phosphoric acid exhibited a broad spectrum of virucidal activity, which reduced the infectivity titre of seven enveloped and four non-enveloped viruses. Expand
Combined oncolytic and vaccination activities of parvovirus H-1 in a metastatic tumor model.
This strategy revealed that the H-1PV infection of tumor cells enhanced their ability to trigger an immune response for which uninfected tumor cells could be the targets, thereby amplifying and taking over from the direct viral oncolytic activity. Expand
Effects of rutin and quercetin on monooxygenase activities in experimental influenza virus infection.
The aim of this work is to study the effect of the flavonoids rutin and quercetin on hepatic monooxygenase activities in experimental influenza virus infection (EIVI), and to find out if these effects could be explained with oxidative hepatic intoxication on the 5th critical day of EIVI. Expand
Interferon γ improves the vaccination potential of oncolytic parvovirus H-1PV for the treatment of peritoneal carcinomatosis in pancreatic cancer
Oncolytic viruses with their capacity to specifically replicate in and kill tumor cells emerged as a novel class of cancer therapeutics. Rat oncolytic parvovirus (H-1PV) was used to treat differentExpand
Chemical composition of Propolis Extract ACF® and activity against herpes simplex virus.
A dual plant origin of PPE was revealed, with components derived from resins of two different species of poplar, and antiviral studies showed that PPE had a pronounced virucidal effect against herpes simplex viruses type 1 and type 2, and also interfered with virus adsorption. Expand
Bulgarians vs the other European populations: a mitochondrial DNA perspective
The observed pattern of mtDNA variation indicates that the Bulgarian mitochondrial pool is geographically homogeneous across the country, and that is characterized by an overall extremely high frequency of western Eurasian lineages. Expand
NGS Nominated CELA1, HSPG2, and KCNK5 as Candidate Genes for Predisposition to Balkan Endemic Nephropathy
It is suggested that an abnormal process of angiogenesis plays a key role in the molecular pathogenesis of BEN, a multifactorial disease with genetic predisposition to environmental risk agents. Expand
Effect of vitamin E supplementation on lipid peroxidation in blood and lung of influenza virus infected mice.
A marked decrease in lipid peroxidation products and an increase in vitamin E content was established in blood and lung on the 5th and 7th day after virus inoculation, and the stabilizing effect of vitamin E is dose-dependent inBlood and dose-independent in lung. Expand
Per aspera ad astra: application of Simplex QSAR approach in antiviral research.
This review explores the application of the Simplex representation of molecular structure (SiRMS) QSAR approach in antiviral research. We provide an introduction to and description of SiRMS, itsExpand
Rimantadine and Oseltamivir Demonstrate Synergistic Combination Effect in an Experimental Infection with Type a (H3N2) Influenza Virus in Mice
Lung virus titre in Madin Darby canine kidney cells, lung index and consolidation score proved the high effectiveness of the combination, and the three-dimensional method of Prichard and Shipman characterized the combination effect as synergistic. Expand