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Autolysins of Bacillus subtilis: multiple enzymes with multiple functions.
Proposals that autolysins are involved in numerous cellular processes including cell growth, cell-wall turnover, peptidoglycan maturation, cell division, separation, motility, chemotaxis, genetic competence, protein secretion, differentiation and pathogenicity are proposed. Expand
Human cytochrome P450 CYP2A13: predominant expression in the respiratory tract and its high efficiency metabolic activation of a tobacco-specific carcinogen,
Findings suggest that CYP2A13 plays important roles in xenobiotic toxicity and tobacco-related tumorigenesis in the human respiratory tract. Expand
Genetic Diversity among Botulinum Neurotoxin-Producing Clostridial Strains
These analyses contribute to the understanding of the evolution and phylogeny within this species and assist in the development of improved diagnostics and therapeutics for the treatment of botulism. Expand
The three-dimensional structure of canine parvovirus and its functional implications.
The three-dimensional atomic structure of a single-stranded DNA virus has been determined and some of the amino termini of VP-2 run to the exterior in full but not empty virions, which is consistent with the observation that someVP-2 polypeptides in full particles can be cleaved by trypsin. Expand
Potent neutralization of botulinum neurotoxin by recombinant oligoclonal antibody
The results indicate that the potency of the polyclonal humoral immune response can be deconvoluted to a few mAbs binding nonoverlapping epitopes, providing a route to drugs for preventing and treating botulism and diseases caused by other pathogens and biologic threat agents. Expand
Plasma and Tissue Levels of Tea Catechins in Rats and Mice During Chronic Consumption of Green Tea Polyphenols
It is suggested that consumption of tea by rodents could induce adaptive responses affecting blood and tissue levels of tea catechins with time and that investigation of a similar phenomenon in humans is warranted. Expand
Antiviral agent blocks breathing of the common cold virus.
Protein mass mapping of the common cold virus, human rhinovirus 14, revealed both viral structural dynamics and the inhibition of such dynamics with an antiviral agent, WIN 52084, indicating that the binding of the antiviralAgent not only causes local conformational changes in the drug binding pocket but actually stabilizes the entire viral capsid against enzymatic degradation. Expand
Sequence Variation within Botulinum Neurotoxin Serotypes Impacts Antibody Binding and Neutralization
ABSTRACT The botulinum neurotoxins (BoNTs) are category A biothreat agents which have been the focus of intensive efforts to develop vaccines and antibody-based prophylaxis and treatment. SuchExpand
Crystal structure of human rhinovirus serotype 1A (HRV1A).
Differential charge distribution of amino acid residues in the "canyon", the putative receptor binding site, provides a possible explanation for the difference in minor versus major receptor group specificities, represented by HRV1A and HRV14, respectively. Expand
The structure of bovine glutamate dehydrogenase provides insights into the mechanism of allostery.
It is proposed that the antenna serves as an intersubunit communication conduit during negative cooperativity and allosteric regulation in bovine GDH, and may represent hexamer interactions in solution and, perhaps, with other enzymes within the mitochondrial matrix. Expand