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diprafenone

Known as: (+-)-2'-(2-Hydroxy-3-(tert-pentylamino)propoxy)-3-phenylpropiophenone 
National Institutes of Health

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3 relations

Broader (2)

Anti-Arrhythmia AgentsPropafenone
analogs & derivatives

Papers overview

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1996
1996
Influence of food on the bioavailability and some pharmacokinetic parameters of diprafenone – a novel antiarrhythmic agent
Objective: The present study was done to investigate the effect of food on the bioavailability of diprafenone.Methods:The most… 
1992
1992
Electrophysiological effects of diprafenone, a dimethyl congener of propafenone on guinea‐pig ventricular cells
1 The effects of diprafenone and propafenone on transmembrane action potential were examined and compared in papillary muscles… 
1991
1991
Characterization of the β‐Adrenoceptor Blocking Property of Diprafenone in Rats: Stereoselective Interaction, Subtype Specificity, and sensitization
Because of their structural relationship to propranolol, propafenone and diprafenone display (β-adreno ceptor blocking activity… 
1991
1991
Direct separation of the enantiomers of propafenone, diprafenone and their major metabolites by high-performance liquid chromatography on modified cellulose and amylose chiral stationary phases.
1988
1988
Block of single cardiac Na+ channels by antiarrhythmic drugs: The effect of amiodarone, propafenone and diprafenone
SummaryCell-attached patch-clamp experiments were performed in cultured cardicyytes of neonatal rats at 19°C to analyze… 
1988
1988
[Diprafenone--comparative study of anti-arrhythmia therapy with propafenone].
Diprafenone is a new antiarrhythmic agent with a dominant local anesthetic action and additional beta-sympathicolytic activity… 
1987
1987
[Electrophysiologic and hemodynamic effects of the new anti-arrhythmia agent diprafenone].
Diprafenone is a new antiarrhythmic agent currently under clinical investigation, with close chemical similarity to propafenone… 
1987
1987
Use of diprafenone, a new potent propafenone-analogue, in acute experimental myocardial ischaemia and infarction.
Diprafenone (D) is a new class I c antiarrhythmic agent, structurally similar to propafenone. We assessed its antiarrhythmic and… 
1986
1986
[Electrophysiologic effects of diprafenone in supraventricular and ventricular tachycardia].
The electrophysiologic effects of diprafenone were evaluated in 31 patients (9 X AV nodal reentrant tachycardia, 9 X Wolff… 
1985
1985
Assessment of the antiarrhythmic profile of the new class I agent diprafenone.
The antiarrhythmic profile of the new compound diprafenone was evaluated using various dog models relevant to conditions in… 
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