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diprafenone

Known as: (+-)-2'-(2-Hydroxy-3-(tert-pentylamino)propoxy)-3-phenylpropiophenone 
National Institutes of Health

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3 relations

Broader (2)

Anti-Arrhythmia AgentsPropafenone
analogs & derivatives

Papers overview

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1996
1996
Influence of food on the bioavailability and some pharmacokinetic parameters of diprafenone – a novel antiarrhythmic agent
Objective: The present study was done to investigate the effect of food on the bioavailability of diprafenone.Methods:The most… 
1992
1992
Electrophysiological effects of diprafenone, a dimethyl congener of propafenone on guinea‐pig ventricular cells
1 The effects of diprafenone and propafenone on transmembrane action potential were examined and compared in papillary muscles… 
1991
1991
The effects of the stereoisomers of propafenone and diprafenone in guinea‐pig heart
1 Optically pure enantiomers of propafenone and diprafenone were prepared from their racemic mixtures and tested for their… 
1991
1991
Characterization of the β‐Adrenoceptor Blocking Property of Diprafenone in Rats: Stereoselective Interaction, Subtype Specificity, and sensitization
Because of their structural relationship to propranolol, propafenone and diprafenone display (β-adreno ceptor blocking activity… 
1989
1989
On the Mechanism of Drug‐Induced Blockade of Na+ Currents: Interaction of Antiarrhythmic Compounds With DPI‐Modified Single Cardiac Na+ Channels
In patch-clamped membranes from neonatal rat cardiocytes, elementary Na+ currents were recorded at 19°C for study of the… 
1989
1989
β‐Adrenoceptor Blocking Activity of Diprafenone in Anesthetized Dogs: Comparison with Propafenone and Propranolol
The effects of diprafenone, a new class Ic antiarrhythmic agent, on canine hemodynamics and cardiac membrane β-receptor… 
1988
1988
Block of single cardiac Na+ channels by antiarrhythmic drugs: The effect of amiodarone, propafenone and diprafenone
SummaryCell-attached patch-clamp experiments were performed in cultured cardicyytes of neonatal rats at 19°C to analyze… 
1987
1987
[Electrophysiologic and hemodynamic effects of the new anti-arrhythmia agent diprafenone].
Diprafenone is a new antiarrhythmic agent currently under clinical investigation, with close chemical similarity to propafenone… 
1986
1986
[Electrophysiologic effects of diprafenone in supraventricular and ventricular tachycardia].
The electrophysiologic effects of diprafenone were evaluated in 31 patients (9 X AV nodal reentrant tachycardia, 9 X Wolff… 
1985
1985
Assessment of the antiarrhythmic profile of the new class I agent diprafenone.
The antiarrhythmic profile of the new compound diprafenone was evaluated using various dog models relevant to conditions in… 
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