dihydrouracil

 
National Institutes of Health

Topic mentions per year

Topic mentions per year

1954-2017
051019542016

Papers overview

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2010
2010
This study investigated the relationship between the dihydrouracil/uracil (UH(2)/U) plasma ratio, a surrogate marker of… (More)
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2004
2004
1. In many cancer patients, 5-fluorouracil (5-FUra) treatment is toxic and even causes death. Nevertheless, all patients are… (More)
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2004
2004
Dihydropyrimidine dehydrogenase (DPD) deficiency in patients causes severe toxicities in 5-fluorouracil/floxuridine (5-FU/FUDR… (More)
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2002
2002
In mammalian cells, thymine glycols and other oxidized pyrimidines such as 5,6-dihydrouracil are removed from DNA by the NTH1… (More)
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1999
1999
PURPOSE Patients with genetic fluorouracil (5-FU) catabolic deficiencies are at high risk for severe toxicity. To predict 5-FU… (More)
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Highly Cited
1996
Highly Cited
1996
We have focused our attention on the development of a novel form of a tegafur-based [FT; a prodrug of 5-fluorouracil (5-FU… (More)
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1995
1995
Dihydrouracil (DHU) is a major base damage product formed from cytosine following exposure of DNA to ionizing radiation under… (More)
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Highly Cited
1987
Highly Cited
1987
The inhibitory effects of about 30 compounds, mainly pyrimidine and pyridine derivatives, on 5-fluorouracil degradation catalyzed… (More)
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1986
1986
Dihydrouracil dehydrogenase activity, with 5-fluorouracil used as the substrate, was measured in human tissues and leukemic cells… (More)
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Highly Cited
1985
Highly Cited
1985
Enzymes of the pyrimidine base catabolism, dihydrouracil dehydrogenase (EC 1.3.1.2), dihydropyrimidinase (EC 3.5.2.2), and beta… (More)
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