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diguanylate cyclase activity

Catalysis of the reaction: 2 GTP = cyclic di-3',5'-guanylate + 2 diphosphate + 2 H(+). [EC:2.7.7.65, RHEA:24901]
National Institutes of Health

Papers overview

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2016
2016
Cyclic diguanosine monophosphate (c-di-GMP) is one of the most important bacterial second messengers that controls many bacterial… 
Highly Cited
2013
Highly Cited
2013
ABSTRACT WspR is a hybrid response regulator-diguanylate cyclase that is phosphorylated by the Wsp signal transduction complex in… 
Highly Cited
2012
Highly Cited
2012
ABSTRACT Although little is known regarding the mechanism of biofilm dispersion, it is becoming clear that this process coincides… 
Highly Cited
2011
Highly Cited
2011
GGDEF and EAL/HD-GYP protein domains are responsible for the synthesis and hydrolysis of the bacterial secondary messenger cyclic… 
Highly Cited
2009
Highly Cited
2009
In Gram-negative bacteria, production of bis-(3′,5′)-cyclic diguanylic acid (c-di-GMP) by diguanylate cyclases (DGCs) is the main… 
Highly Cited
2009
Highly Cited
2009
ABSTRACT Anaplasma phagocytophilum, the etiologic agent of human granulocytic anaplasmosis (HGA), has genes predicted to encode… 
Highly Cited
2007
Highly Cited
2007
ABSTRACT The intracellular signaling molecule, cyclic-di-GMP (c-di-GMP), has been shown to influence bacterial behaviors… 
Highly Cited
2006
Highly Cited
2006
ABSTRACT Flagellar biogenesis and hence motility of Vibrio fischeri depends upon the presence of magnesium. In the absence of… 
Highly Cited
2001
Highly Cited
2001
A conserved domain, called GGDEF (referring to a conserved central sequence pattern), is detected in many procaryotic proteins…