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diftalone

Known as: aladione, phthalazino-(2,3-b)-phthalazine-5,12(7H,14H)-dione 
National Institutes of Health

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Broader (1)

Pyridazines

Papers overview

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Review
1983
Review
1983
Food interactions affecting the absorption of analgesic and anti-inflammatory agents.
Food interactions affect the absorption of most analgesic and anti-inflammatory agents. Of the 18 compounds that have been… 
1979
1979
The guinea pig neutrophil calcium-dependent lysosomal enzyme secretory process.
1978
1978
Nonsteroid anti-inflammatory agents: regulators of the phagocytic secretion of lysosomal enzymes from guinea-pig neutrophils.
Several nonsteroid anti-inflammatory agents were evaluated for their capacity to modulate phagocytosis by and lysosomal enzyme… 
1978
1978
The effect of repeated administration of diftalone on enzyme induction
Plasma concentrations of diftalone have been examined in normal volunteers after a single dose (500 mg) and after 500 mg doses… 
Highly Cited
1977
Highly Cited
1977
Aspects of bronchial reactivity to prostaglandins and aspirin in asthmatic patients.
The behaviour of bronchial reactivity to PGF2alpha was studied in asthmatic patients under various experimental conditions… 
1977
1977
Influence of food intake on the absorption of diftalone in man.
An average 2.2-fold increase in the peak plasma concentrations of the non-steroidal anti-inflammatory agent diftalone in the… 
1976
1976
Comparative clinical trial with a new substance, Diftalone, versus indomethacin in 30 patients affected with rheumatoid arthritis.
During a double-blind, randomized study on 30 patients affected with classic or definite rheumatoid arthritis, the efficacy and… 
1975
1975
Effect of Diftalone and other Nonsteroidal Anti-inflammatory Agents on Synthesis of Prostaglandins
Summary Diftalone and its metabolites 7,14-Dihydroxyphthalazino [2,3-b]phthal-azine-5,12 (7H, 14H)-dione, 7-Hydroxy-phthalazino… 
1975
1975
The therapeutic activity of diftalone in rheumatoid arthritis: crossover comparison with indomethacin.
A multi-centre double-blind crossover study was carried out in 70 hospitalised patients with rheumatoid arthritis to compare the… 
1974
1974
Long-Term Controlled Clinical Trial of a New Anti-Inflammatory Drug, Diftalone, in Rheumatoid Arthritis
A long-term (two years) double-blind, comparative trial of diftalone (Aladione ®) 500 mg versus indomethacin 75 mg per day, in… 
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