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The pharmacokinetics of diclofenac sodium following intravenous and oral administration
- J. Willis, M. Kendall, R. Flinn, D. Thornhill, P. Welling
- Medicine, BiologyEuropean Journal of Clinical Pharmacology
The pharmacokinetics of diclofenac were examined following single rapid intravenous injection and also following single oral doses to healthy female volunteers, finding that Fifty percent of orally dosed dic lofenacs did not reach the systemic circulation due, predominantly, to first-pass metabolism.
Pharmacokinetics of probenecid following oral doses to human volunteers.
It is suggested that probenecid elimination may be saturable at therapeutic dose levels following single 0.5, 1.0, and 2.0-g oral doses to healthy male volunteers, and that the model fitted to the saturable elimination model resulted in a plasma drug half-life of 8.5 hr.
Multiple-dose pharmacokinetics and safety of ciprofloxacin in normal volunteers
- M. A. González, F. Uribe, B. Painter
- Medicine, BiologyAntimicrobial Agents and Chemotherapy
- 1 November 1984
The multiple-dose pharmacokinetics and safety of ciprofloxacin, a new quinoline carboxylic acid derivative, were evaluated in normal volunteers and it was found that the drug was well tolerated.
Bioavailability of hydrochlorothiazide from tablets and suspensions.
The systematic availability of hydrochlorothiazide, unlike that of chlorothiazides, is dose proportional in the therapeutic range, and the dose increases in electrolyte excretion among the treatments during the 0-12-h postdose period are no differences.
Protein Binding of Antimicrobials: Clinical Pharmacokinetic and Therapeutic Implications
Tissue and extravascular fluid drug levels are primarily influenced by the free drug levels in serum, but calculation of actual tissue levels is complicated by variable binding characteristics of specific tissues and tissue fluids, and also by the lipophilic nature of the drug.
THE EFFECTS OF FOOD ON DRUG ABSORPTION
- P. Welling
- Biology, MedicineAnnual review of nutrition
This chapter provides an update on drug-food interactions reported in the literature during the past five years and additional avenues need to be explored to seek mechanistic patterns that may lead to better prediction of the nature and extent of changes in circulating drug levels due to the presense of food.
Pharmacokinetics of cefuroxime in normal and impaired renal function: comparison of high-pressure liquid chromatography and microbiological assays
- R. Bundtzen, R. D. Toothaker, O. S. Nielson, P. Madsen, P. Welling, W. Craig
- MedicineAntimicrobial Agents and Chemotherapy
- 1 March 1981
The pharmacokinetics of cefuroxime were studied after a single dose of 750 mg was given intravenously to each of 21 male volunteers grouped according to their creatinine clearances, which yielded statistically identical results, except for serum levels in uremic patients (group 3).
Clinical Pharmacokinetics of Co-trimoxazole (trimethoprim-sulphamethoxazole)
The combination trimethoprim-sulphamethoxazole (co-trimoxazole) is used clinically for the treatment of a variety of infections due to Gram-positive and Gram-negative organisms; particularly for…
The Clinical Pharmacokinetics of Quinapril
- S. Olson, A. M. Horvath, B. Michniewicz, A. Sedman, W. Colburn, P. Welling
- Medicine, BiologyAngiology
- 1 April 1989
The absorption of Q and conversion to QT is rapid and dose-proportional, subsequent clear ance of both Q andQT is independ ent of dose, and metabolism to compounds other than QT are not ex tensive.