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difluorotoluene

Known as: 2,4-difluorotoluene, 2F-toluene 
National Institutes of Health

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2 relations

Broader (1)

Toluene
analogs & derivatives

Papers overview

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2012
2012
Structural basis for differential insertion kinetics of dNMPs opposite a difluorotoluene nucleotide residue.
We have recently challenged the widely held view that 2,4-difluorotoluene (dF) is a nonpolar isosteric analogue of the nucleotide… 
2011
2011
Hydrogen-bonding capability of a templating difluorotoluene nucleotide residue in an RB69 DNA polymerase ternary complex.
Results obtained using 2,4-difluorotoluene nucleobase (dF) as a nonpolar thymine isostere by Kool and colleagues challenged the… 
2008
2008
Solution structure of a DNA duplex containing a guanine-difluorotoluene pair: a wobble pair without hydrogen bonding?
The incorporation of synthetic nucleoside analogues into DNA duplexes provides a unique opportunity to probe both structure and… 
Review
2006
Review
2006
The difluorotoluene debate--a decade later.
2,4-Difluorotoluene is unusual among hydrofluorocarbons because it is shaped like the DNA base thymine. It was first synthesised… 
2005
2005
A series of nonpolar thymidine analogues of increasing size: DNA base pairing and stacking properties.
[reaction: see text] We describe the properties in DNA of a set of five nonpolar nucleoside mimics in which shape is similar but… 
2004
2004
DNA ligases ensure fidelity by interrogating minor groove contacts.
DNA ligases, found in both prokaryotes and eukaryotes, covalently link the 3'-hydroxyl and 5'-phosphate ends of duplex DNA… 
1999
1999
Molecular moment similarity between several nucleoside analogs of thymidine and thymidine. sil@watson.ibm.com.
Molecular moment descriptors of the shape and charge distributions of twenty five nucleoside structures have been examined. The… 
Highly Cited
1997
Highly Cited
1997
Highly Precise Shape Mimicry by a Difluorotoluene Deoxynucleoside, a Replication-Competent Substitute for Thymidine.
Until recently, the large majority of studies of the origins of DNA replication fidelity have concluded that complementarity of… 
1997
1997
Quantum-chemical ab initio study on the adenine-difluorotoluene complex--a mimic for the adenine-thymine base pair.
Recent experiments have shown that difluorotoluene (F), a nonpolar isostere for thymine (T), codes efficiently and specifically… 
1997
1997
Bi-stranded, multisite replication of a base pair between difluorotoluene and adenine: confirmation by 'inverse' sequencing.
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