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difluorotoluene

Known as: 2,4-difluorotoluene, 2F-toluene 
National Institutes of Health

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2 relations

Broader (1)

Toluene
analogs & derivatives

Papers overview

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2012
2012
Structural basis for differential insertion kinetics of dNMPs opposite a difluorotoluene nucleotide residue.
We have recently challenged the widely held view that 2,4-difluorotoluene (dF) is a nonpolar isosteric analogue of the nucleotide… 
2011
2011
Hydrogen-bonding capability of a templating difluorotoluene nucleotide residue in an RB69 DNA polymerase ternary complex.
Results obtained using 2,4-difluorotoluene nucleobase (dF) as a nonpolar thymine isostere by Kool and colleagues challenged the… 
2010
2010
Abstract 1697: A study on the reactivity of activated polycyclic aromatic hydrocarbons (PAH) with guanines base pared to C-5 substituted cytosines
Proceedings: AACR 101st Annual Meeting 2010‐‐ Apr 17‐21, 2010; Washington, DC All CG dinucleotides within exons 5-8 of the human… 
2008
2008
Solution structure of a DNA duplex containing a guanine-difluorotoluene pair: a wobble pair without hydrogen bonding?
The incorporation of synthetic nucleoside analogues into DNA duplexes provides a unique opportunity to probe both structure and… 
2005
2005
A series of nonpolar thymidine analogues of increasing size: DNA base pairing and stacking properties.
[reaction: see text] We describe the properties in DNA of a set of five nonpolar nucleoside mimics in which shape is similar but… 
Highly Cited
2003
Highly Cited
2003
Requirement of Watson-Crick Hydrogen Bonding for DNA Synthesis by Yeast DNA Polymerase η
ABSTRACT Classical high-fidelity DNA polymerases discriminate between the correct and incorrect nucleotides by using geometric… 
1999
1999
Molecular moment similarity between several nucleoside analogs of thymidine and thymidine. sil@watson.ibm.com.
Molecular moment descriptors of the shape and charge distributions of twenty five nucleoside structures have been examined. The… 
Highly Cited
1997
Highly Cited
1997
Highly Precise Shape Mimicry by a Difluorotoluene Deoxynucleoside, a Replication-Competent Substitute for Thymidine.
Until recently, the large majority of studies of the origins of DNA replication fidelity have concluded that complementarity of… 
1997
1997
Quantum-chemical ab initio study on the adenine-difluorotoluene complex--a mimic for the adenine-thymine base pair.
Recent experiments have shown that difluorotoluene (F), a nonpolar isostere for thymine (T), codes efficiently and specifically… 
1997
1997
Bi-stranded, multisite replication of a base pair between difluorotoluene and adenine: confirmation by 'inverse' sequencing.
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