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Role of Tet proteins in 5mC to 5hmC conversion, ES-cell self-renewal and inner cell mass specification
DNA methylation is one of the best-characterized epigenetic modifications. Although the enzymes that catalyse DNA methylation have been characterized, enzymes responsible for demethylation have beenExpand
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Endogenous bile acids are ligands for the nuclear receptor FXR/BAR.
The major metabolic pathway for elimination of cholesterol is via conversion to bile acids. In addition to this metabolic function, bile acids also act as signaling molecules that negatively regulateExpand
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Oxidative damage to methyl-CpG sequences inhibits the binding of the methyl-CpG binding domain (MBD) of methyl-CpG binding protein 2 (MeCP2).
Cytosine methylation in CpG dinucleotides is believed to be important in gene regulation, and is generally associated with reduced levels of transcription. Methylation-mediated gene silencingExpand
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Endogenous cytosine damage products alter the site selectivity of human DNA maintenance methyltransferase DNMT1.
Alterations in cytosine methylation patterns are usually observed in human tumors. The consequences of altered cytosine methylation patterns include both inappropriate activation of transformingExpand
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Dynamics of mismatched base pairs in DNA.
The structural dynamics of mismatched base pairs in duplex DNA have been studied by time-resolved fluorescence anisotropy decay measurements on a series of duplex oligodeoxynucleotides of the generalExpand
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Comparison between DNA melting thermodynamics and DNA polymerase fidelity.
The relation between DNA polymerase fidelity and base pairing stability is investigated by using DNA primer-template duplexes that contain a common 9-base template sequence but have either correctExpand
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Reverse chemical mutagenesis: identification of the mutagenic lesions resulting from reactive oxygen species-mediated damage to DNA.
An understanding of the contribution of reactive oxygen species to mutagenesis has been hampered by the vast number of different chemical modifications they cause in DNA. Even though many of theseExpand
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The abasic site as a challenge to DNA polymerase. A nuclear magnetic resonance study of G, C and T opposite a model abasic site.
An abasic site in DNA creates a strong block to DNA polymerase and is a mutagenic base lesion. In this study, we present structural and dynamic properties of duplex oligodeoxynucleotides containingExpand
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Comparison of nucleotide interactions in water, proteins, and vacuum: model for DNA polymerase fidelity.
We propose a model for DNA polymerase fidelity in which free energy differences, delta delta G, between matched and mismatched nucleotides are magnified at the enzyme's active site. Both hydrogenExpand
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Mechanism of human methyl-directed DNA methyltransferase and the fidelity of cytosine methylation.
The properties of the methyl-directed DNA (cytosine-5-)-methyltransferase (EC suggest that it is the enzyme that maintains patterns of methylation in the human genome. Proposals for theExpand
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