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The crystal structure of the complex of blood coagulation factor VIIa with soluble tissue factor
Blood coagulation is initiated when tissue factor binds to coagulation factor Vila to give an enzymatically active complex which then activates factors IX and X, leading to thrombin generation andExpand
Crystal structure of a pol alpha family replication DNA polymerase from bacteriophage RB69.
The 2.8 A resolution crystal structure of the bacteriophage RB69 gp43, a member of the eukaryotic pol alpha family of replicative DNA polymerases, shares some similarities with other polymerases butExpand
Crystal Structure of a pol α Family Replication DNA Polymerase from Bacteriophage RB69
Abstract The 2.8 A resolution crystal structure of the bacteriophage RB69 gp43, a member of the eukaryotic pol α family of replicative DNA polymerases, shares some similarities with other polymerasesExpand
Crystal structure of a replication fork single-stranded DNA binding protein (T4 gp32) complexed to DNA
THE single-stranded DNA (ssDNA) binding protein gp32 from bacteriophage T4 is essential for T4 DNA replication, recombination and repair. In vivo gp32 binds ssDNA as the replication fork advances andExpand
High-frequency generalised transduction by bacteriophage T4
GENERALISED transduction—the transfer of bacterial genes from one cell to another via bacteriophages—is one of a small number of processes by which bacteria can acquire exogenous genetic information.Expand
Two proton transfers in the transition state for nucleotidyl transfer catalyzed by RNA- and DNA-dependent RNA and DNA polymerases
The rate-limiting step for nucleotide incorporation in the pre-steady state for most nucleic acid polymerases is thought to be a conformational change. As a result, very little information isExpand
Structural and Biochemical Investigation of the Role in Proofreading of a β Hairpin Loop Found in the Exonuclease Domain of a Replicative DNA Polymerase of the B Family*
Replicative DNA polymerases, as exemplified by the B family polymerases from bacteriophages T4 and RB69, not only replicate DNA but also have the ability to proofread misincorporated nucleotides.Expand
Tissue factor promotes melanoma metastasis by a pathway independent of blood coagulation.
Several studies have established a link between blood coagulation and cancer, and more specifically between tissue factor (TF), a transmembrane protein involved in initiating blood coagulation, andExpand
Isolation of cDNA clones coding for human tissue factor: primary structure of the protein and cDNA.
Tissue factor is a membrane-bound procoagulant protein that activates the extrinsic pathway of blood coagulation in the presence of factor VII and calcium. lambda Phage containing the tissue factorExpand
Adsorption protein of the bacteriophage fd: isolation, molecular properties, and location in the virus.
The adsorption (minor coat) protein of the bacteriophage fd has been implicated to function in several steps of viral morphogenesis. The protein has been purified by sodium dodecyl sulfate gelExpand
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