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differentiation therapy

Known as: therapy, differentiation 
Drug therapy aimed at forcing cancer cells to resume the process of maturation and therefore to induce tumor to a more differentiated, less… Expand
National Institutes of Health

Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
Review
2018
Review
2018
The concept of differentiation therapy emerged from the fact that hormones or cytokines may promote differentiation ex vivo… Expand
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Highly Cited
2013
Highly Cited
2013
A number of human cancers harbor somatic point mutations in the genes encoding isocitrate dehydrogenases 1 and 2 (IDH1 and IDH2… Expand
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Highly Cited
2009
Highly Cited
2009
Since their discovery in the early 2000s, microRNAs (miRNAs) and their penchant for RNA interference have taken the scientific… Expand
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Highly Cited
2009
Highly Cited
2009
PURPOSE The effects of pan-histone deacetylase (HDAC) inhibitors on cancer cells have shown that HDACs are involved in… Expand
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Review
2006
Review
2006
A wide range of studies suggest that most cancers are clonal and may represent the progeny of a single cell, a cancer stem cell… Expand
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Highly Cited
2001
Highly Cited
2001
Histone deacetylases (HDACs) play important roles in transcriptional regulation and pathogenesis of cancer. Thus, HDAC inhibitors… Expand
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Review
2001
Review
2001
Current cancer therapies are highly toxic and often nonspecific. A potentially less toxic approach to treating this prevalent… Expand
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Highly Cited
2001
Highly Cited
2001
Histone deacetylase (HDAC)-dependent transcriptional repression of the retinoic acid (RA)-signaling pathway underlies the… Expand
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Highly Cited
1999
Highly Cited
1999
N-CoR and SMRT are transcriptional corepressors that associate with nuclear hormone receptors (NRs) in the absence of ligand… Expand
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Highly Cited
1996
Highly Cited
1996
Hybrid polar compounds, of which hexamethylenebisacetamide (HMBA) is the prototype, are potent inducers of differentiation of… Expand
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