differentiation therapy

Known as: therapy, differentiation 
Drug therapy aimed at forcing cancer cells to resume the process of maturation and therefore to induce tumor to a more differentiated, less… (More)
National Institutes of Health

Topic mentions per year

Topic mentions per year

1986-2017
0102019862017

Papers overview

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Highly Cited
2013
Highly Cited
2013
A number of human cancers harbor somatic point mutations in the genes encoding isocitrate dehydrogenases 1 and 2 (IDH1 and IDH2… (More)
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2011
2011
Breast cancer stem cells (BCSCs) are the source of breast tumors. Compared with other cancer cells, cancer stem cells show high… (More)
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2009
2009
Since their discovery in the early 2000s, microRNAs (miRNAs) and their penchant for RNA interference have taken the scientific… (More)
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Highly Cited
2009
Highly Cited
2009
PURPOSE The effects of pan-histone deacetylase (HDAC) inhibitors on cancer cells have shown that HDACs are involved in… (More)
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Highly Cited
2008
Highly Cited
2008
UNLABELLED Previous studies have shown that hepatocyte nuclear factor-4alpha (HNF4alpha) is a central regulator of differentiated… (More)
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Highly Cited
2004
Highly Cited
2004
Chemical genomics involves generating large collections of small molecules and using them to modulate cellular states. Despite… (More)
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Highly Cited
2001
Highly Cited
2001
Histone deacetylases (HDACs) play important roles in transcriptional regulation and pathogenesis of cancer. Thus, HDAC inhibitors… (More)
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Highly Cited
2001
Highly Cited
2001
Histone deacetylase (HDAC)-dependent transcriptional repression of the retinoic acid (RA)-signaling pathway underlies the… (More)
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Highly Cited
1999
Highly Cited
1999
Array technologies have made it straightforward to monitor simultaneously the expression pattern of thousands of genes. The… (More)
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Highly Cited
1996
Highly Cited
1996
Hybrid polar compounds, of which hexamethylenebisacetamide (HMBA) is the prototype, are potent inducers of differentiation of… (More)
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