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Multi-Organ, Multi-Lineage Engraftment by a Single Bone Marrow-Derived Stem Cell
Purification of rare hematopoietic stem cell(s) (HSC) to homogeneity is required to study their self-renewal, differentiation, phenotype, and homing. Long-term repopulation (LTR) of irradiated hosts… Expand
CD34: structure, biology, and clinical utility.
Stromal Cell–Derived Factor-1α Plays a Critical Role in Stem Cell Recruitment to the Heart After Myocardial Infarction but Is Not Sufficient to Induce Homing in the Absence of Injury
- J. D. Abbott, Yan Huang, D. Liu, R. Hickey, D. Krause, F. Giordano
- 23 November 2004
Background—After myocardial infarction (MI), bone marrow–derived cells (BMDCs) are found within the myocardium. The mechanisms determining BMDC recruitment to the heart remain unclear. We… Expand
Liver from bone marrow in humans
It has been shown in animal models that hepatocytes and cholangiocytes can derive from bone marrow cells. We have investigated whether such a process occurs in humans. Archival autopsy and biopsy… Expand
Bone marrow stem cells contribute to repair of the ischemically injured renal tubule.
- S. Kale, A. Karihaloo, P. R. Clark, M. Kashgarian, D. Krause, L. Cantley
- The Journal of clinical investigation
- 1 July 2003
The paradigm for recovery of the renal tubule from acute tubular necrosis is that surviving cells from the areas bordering the injury must migrate into the regions of tubular denudation and… Expand
SALL4, a novel oncogene, is constitutively expressed in human acute myeloid leukemia (AML) and induces AML in transgenic mice.
SALL4, a human homolog to Drosophila spalt, is a novel zinc finger transcriptional factor essential for development. We cloned SALL4 and its isoforms (SALL4A and SALL4B). Through immunohistochemistry… Expand
Safety and immunogenicity of hepatitis A vaccine in patients with chronic liver disease
Acute hepatitis A superimposed on chronic liver disease (CLD) has been associated with severe or fulminant hepatitis. An open, multicenter study was performed to compare the safety and immunogenicity… Expand
Lack of a Fusion Requirement for Development of Bone Marrow-Derived Epithelia
- R. Harris, E. Herzog, E. Bruscia, Joanna E Grove, John S Van Arnam, D. Krause
- Biology, Medicine
- 2 July 2004
Analysis of developmental plasticity of bone marrow–derived cells (BMDCs) is complicated by the possibility of cell-cell fusion. Here we demonstrate that epithelial cells can develop from BMDCs… Expand
Characterization of murine CD34, a marker for hematopoietic progenitor and stem cells.
CD34 is expressed on human hematopoietic stem and progenitor cells, and its clinical usefulness for the purification of stem cells has been well established. However, a similar pattern of expression… Expand
Abnormal Trafficking and Degradation of TLR4 Underlie the Elevated Inflammatory Response in Cystic Fibrosis
Morbidity and mortality in cystic fibrosis (CF) are due not only to abnormal epithelial cell function, but also to an abnormal immune response. We have shown previously that macrophages lacking CF… Expand