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diacylglycerol biosynthetic process

Known as: diacylglycerol formation, diacylglycerol biosynthesis, diacylglycerol anabolism 
The chemical reactions and pathways resulting in the formation of diacylglycerol, a glyceride in which any two of the R groups (positions not… Expand
National Institutes of Health

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2 relations
negative regulation of diacylglycerol biosynthetic processpositive regulation of diacylglycerol biosynthetic process

Papers overview

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Highly Cited
2002
Highly Cited
2002
Hyperglycemia-induced apoptosis in human umbilical vein endothelial cells: inhibition by the AMP-activated protein kinase activation.
Apoptosis has been observed in vascular cells, nerve, and myocardium of diabetic humans and experimental animals, although… Expand
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Highly Cited
1994
Highly Cited
1994
Androgens increase intracellular calcium concentration and inositol 1,4,5-trisphosphate and diacylglycerol formation via a pertussis toxin-sensitive G-protein.
Bone is a target tissue of androgens, but the mechanisms by which they act on bone are still unclear. This study examines the… Expand
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Highly Cited
1990
Highly Cited
1990
Thrombin signal transduction mechanisms in rat vascular smooth muscle cells. Calcium and protein kinase C-dependent and -independent pathways.
Sustained generation of alpha-thrombin and its breakdown forms at sites of thromboses has focused attention on the roles thrombin… Expand
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Highly Cited
1989
Highly Cited
1989
A role for malonyl-CoA in glucose-stimulated insulin secretion from clonal pancreatic beta-cells.
To gain insight into the relationship between acyl coenzyme A (CoA) esters and glucose-induced insulin release, acyl-CoA profiles… Expand
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Highly Cited
1987
Highly Cited
1987
Angiotensin II-stimulated Na+/H+ exchange in cultured vascular smooth muscle cells. Evidence for protein kinase C-dependent and -independent pathways.
Angiotensin II, a potent vasoconstrictor, is known to stimulate Ca2+ mobilization and Na+ influx in vascular smooth muscle cells… Expand
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Highly Cited
1986
Highly Cited
1986
Sustained diacylglycerol formation from inositol phospholipids in angiotensin II-stimulated vascular smooth muscle cells.
Angiotensin II acts on cultured rat aortic vascular smooth muscle cells to stimulate phospholipase C-mediated hydrolysis of… Expand
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Highly Cited
1986
Highly Cited
1986
Regulation of the phosphoinositide hydrolysis pathway in thrombin-stimulated platelets by a pertussis toxin-sensitive guanine nucleotide-binding protein. Evaluation of its contribution to platelet…
In platelets activated by thrombin, the hydrolysis of phosphatidylinositol 4,5-bisphosphate by phospholipase C produces inositol… Expand
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Highly Cited
1983
Highly Cited
1983
Synergistic functions of protein phosphorylation and calcium mobilization in platelet activation.
When human platelets were stimulated by synthetic diacylglycerol such as 1-oleoyl-2-acetyl-glycerol, which was a potent activator… Expand
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Highly Cited
1983
Highly Cited
1983
A role of calcium-activated phospholipid-dependent protein kinase in human platelet activation. Comparison of thrombin and collagen actions.
In human platelets stimulated by thrombin and collagen, diacylglycerol is rapidly produced from phosphatidylinositol… Expand
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Highly Cited
1980
Highly Cited
1980
Phospholipid turnover as a possible transmembrane signal for protein phosphorylation during human platelet activation by thrombin.
Summary Human platelets contain a large amount of Ca2+-activated, phospholipid-dependent protein kinase (protein kinase C). The… Expand
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