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deoxyhypusine monooxygenase

Known as: hDOHH, HEAT-Like Repeat-Containing Protein 1, EC 1.14.99.29 
Deoxyhypusine hydroxylase (302 aa, ~33 kDa) is encoded by the human DOHH gene. This protein is involved in the hydroxylation of lysine to form… 
National Institutes of Health

Related topics

Related topics

8 relations
DOHH geneDOHH wt AlleleEnzyme GeneHomo sapiens

Broader (1)

Mixed Function Oxygenases

Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
2015
2015
New insights into novel inhibitors against deoxyhypusine hydroxylase from plasmodium falciparum: compounds with an iron chelating potential
Deoxyhypusine hydroxylase (DOHH) is a dinuclear iron enzyme required for hydroxylation of the aminobutyl side chain of… 
2015
2015
The Beauty of a Visualized Peroxo-diiron(III) Intermediate.
2014
2014
Erratum to: Chemical profiling of deoxyhypusine hydroxylase inhibitors for antimalarial therapy
A first approach to discover new antimalarials has been recently performed in a combined approach with data from GlaxoSmithKline… 
2014
2014
Therapeutics , Targets , and Chemical Biology Blocking eIF 5 A Modi fi cation in Cervical Cancer Cells Alters the Expression of Cancer-Related Genes and Suppresses Cell Proliferation
Cancer etiology is influenced by alterations in protein synthesis that are not fully understood. In this study, we took a novel… 
Review
2013
Review
2013
Chemical profiling of deoxyhypusine hydroxylase inhibitors for antimalarial therapy
A first approach to discover new antimalarials has been recently performed in a combined approach with data from GlaxoSmithKline… 
Review
2010
Review
2010
Assessment of deoxyhypusine hydroxylase as a putative, novel drug target
Antimalarial drug resistance has nowadays reached each drug class on the market for longer than 10 years. The focus on validated… 
2006
2006
Piperidones with activity against Plasmodium falciparum
The increasing resistance of the malaria parasites has enforced new strategies of finding new drug targets. We have isolated two… 
2004
2004
Screening Assay for the Identification of Deoxyhypusine Synthase Inhibitors
The 1st step in the posttranslational hypusine [Nε-(4-amino-2-hydroxybutyl)lysine] modification of eukaryotic translation… 
1996
1996
Evaluation of the metal ion requirement of the human deoxyhypusine hydroxylase from HeLa cells using a novel enzyme assay
1988
1988
Developmental Pattern for Deoxyhypusine Hydroxylase in Rat Brain
Deoxyhypusine hydroxylase catalyzes the formation of hypusine from deoxyhypusine in a precursor form of eukaryotic initiation… 
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