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DOHH gene

Known as: DEOXYHYPUSINE DIOXYGENASE, MGC4293, DEOXYHYPUSINE MONOOXYGENASE 
This gene is involved in the hydroxylation of lysine.
National Institutes of Health

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DOHH wt Allele
Oxidation-Reductiondeoxyhypusine monooxygenase

Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
2015
2015
New insights into novel inhibitors against deoxyhypusine hydroxylase from plasmodium falciparum: compounds with an iron chelating potential
Deoxyhypusine hydroxylase (DOHH) is a dinuclear iron enzyme required for hydroxylation of the aminobutyl side chain of… 
2014
2014
Therapeutics , Targets , and Chemical Biology Blocking eIF 5 A Modi fi cation in Cervical Cancer Cells Alters the Expression of Cancer-Related Genes and Suppresses Cell Proliferation
Cancer etiology is influenced by alterations in protein synthesis that are not fully understood. In this study, we took a novel… 
2014
2014
Proliferation Expression of Cancer-Related Genes and Suppresses Cell Blocking eIF 5 A Modification in Cervical Cancer Cells Alters the
Cancer etiology is influenced by alterations in protein synthesis that are not fully understood. In this study, we took a novel… 
Review
2013
Review
2013
Chemical profiling of deoxyhypusine hydroxylase inhibitors for antimalarial therapy
A first approach to discover new antimalarials has been recently performed in a combined approach with data from GlaxoSmithKline… 
2011
2011
A rapid and robust assay for the determination of the amino acid hypusine as a possible biomarker for a high-throughput screening of antimalarials and for the diagnosis and therapy of different…
Eukaryotic initiation factor 5A (eIF5A) has recently been identified as a biomarker of prognostic significance and therapeutic… 
Review
2010
Review
2010
Assessment of deoxyhypusine hydroxylase as a putative, novel drug target
Antimalarial drug resistance has nowadays reached each drug class on the market for longer than 10 years. The focus on validated… 
2008
2008
Site‐directed mutagenesis of bovine deoxyhypusine hydroxylase at the hinge loop area
Deoxyhypusine hydroxylase (DOHH) is the second of the two enzymes that catalyze the maturation of eukaryotic initiation factor 5A… 
Highly Cited
1998
Highly Cited
1998
Antiretroviral effects of deoxyhypusyl hydroxylase inhibitors: a hypusine-dependent host cell mechanism for replication of human immunodeficiency virus type 1 (HIV-1).
1997
1997
Detection of somatic mutations of the bcl-2 oncogene in B cell lymphomas with the t(14;18).
The incidence of mutations within the first 582 bp of the open reading frame of the bcl-2 gene, has been investigated in… 
1996
1996
Evaluation of the metal ion requirement of the human deoxyhypusine hydroxylase from HeLa cells using a novel enzyme assay
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