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Background and purpose: There are two important properties of receptor–ligand interactions: affinity (the ability of the ligand… Expand BACKGROUND
Some patients with Brugada syndrome experience an electrical storm of ventricular fibrillation (VF).
The… Expand We investigated the inotropic effect of SCH00013 (4, 5-dihydro-6-[1-[2-hydroxy-2-(4-cyanophenyl)ethyl]-1,2,5, 6-tetrahydropyrido… Expand Recent in vitro evidence shows a role of endothelial nitric oxide (NO) in the modulation of isoproterenol-induced vasorelaxation… Expand 1. The signal transduction process mediated by cyclic AMP that leads to the characteristic positive inotropic effect (PIE) in… Expand In patients with chronic heart failure cardiac beta-1 adrenoceptors are reduced, whereas beta-2 adrenoceptor changes vary… Expand Prenalterol (beta 1-agonist), denopamine (beta 1-agonist), and zinterol (beta 2-agonist) were partial agonists of adenylate… Expand We investigated the detailed mode and mechanism of action of denopamine in canine right ventricular muscle. When administered in… Expand We used radioligand binding techniques and measurement of beta-agonist-mediated positive inotropic responses in isolated cardiac… Expand We used radioligand binding techniques and measurement of β-agonist-mediated positive inotropic responses in isolated cardiac… Expand