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TRPC3 and TRPC6 are essential for angiotensin II‐induced cardiac hypertrophy
TLDR
Data suggest that DAG‐induced Ca2+ signaling pathway through TRPC3 and TRPC6 is essential for Ang II‐induced NFAT activation and cardiac hypertrophy. Expand
P2Y6 receptor‐Gα12/13 signalling in cardiomyocytes triggers pressure overload‐induced cardiac fibrosis
TLDR
Results indicate that activation of Gα12/13 in cardiomyocytes by the extracellular nucleotides‐stimulated P2Y6 receptor triggers fibrosis in pressure overload‐induced cardiac fibrosis, which works as an upstream mediator of the signalling pathway between Ang II and TGF‐β. Expand
Gαi and Gαo are target proteins of reactive oxygen species
TLDR
It is shown that inhibition of the βγ-subunit of G protein (Gβγ) attenuates hydrogen peroxide (H2O2)-induced ERK activation in rat neonatal cardiomyocytes and concludes that Gαi and Gαo are critical targets of oxidative stress for activation of ERK. Expand
Serine Residue in the IIIS5-S6 Linker of the L-type Ca2+ Channel α1C Subunit Is the Critical Determinant of the Action of Dihydropyridine Ca2+Channel Agonists*
TLDR
Results indicate that the hydroxyl group of Ser1115 in IIIS5-S6 linker of the L-type Ca2- channel α1C subunit plays a critical role in DHP binding and in the action of DHP Ca2+ channel agonists. Expand
Novel peptides from assassin bugs (Hemiptera: Reduviidae): isolation, chemical and biological characterization
TLDR
Three novel peptides were isolated from the venomous saliva of predatory reduviids and Ptu1, the shortest peptide, was chemically synthesized and co‐eluted with its native form and electrophysiological experiments demonstrated that sPtu1 reversibly blocks the N‐type calcium channels expressed in BHK cells. Expand
Gα12/13- and Reactive Oxygen Species-dependent Activation of c-Jun NH2-terminal Kinase and p38 Mitogen-activated Protein Kinase by Angiotensin Receptor Stimulation in Rat Neonatal Cardiomyocytes*
TLDR
The results suggest that Gα12/13-mediated ROS production through Rho and Rac is essential for JNK and p38 MAPK activation. Expand
The putative phospholipase C inhibitor U73122 and its negative control, U73343, elicit unexpected effects on the rabbit parietal cell.
TLDR
The widely used PLC-inhibitor, U73122, and its negative control, U73343, are both useless as tools for analyzing the role of PLC in rabbit parietal cells because the former is ineffective on gastric PLC and works as an intracellular calcium releaser, and the latter works as a protonophore. Expand
The role of the seventh transmembrane region in high affinity binding of a beta 2-selective agonist TA-2005.
TLDR
Results indicate that Tyr308 is an essential amino acid for high affinity binding of the beta 2-selective agonist TA-2005, an alanine-scanning mutagenesis approach that suggested that the TM7 region of thebeta 2AR plays an important role in beta 1AR subtype selective agonist binding. Expand
Gene expression profiling of human mesenchymal stem cells for identification of novel markers in early- and late-stage cell culture.
TLDR
The results showed that the osteogenic differentiation capacity of hMSCs is down-regulated in the late stages of cell culture, and it seemed that adipogenic differentiationcapacity was also down- regulated in late stage of the culture. Expand
Translocation of HSP27 to cytoskeleton by repetitive hypoxia-reoxygenation in the rat myoblast cell line, H9c2.
TLDR
The changes in localization of HSP27 found in the present study may reflect the mechanism of preconditioning in the cardiac myocyte. Expand
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