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delafloxacin

Known as: 1-(6-Amino-3,5-Difluoropyridin-2-Yl)-8-Chloro-6-Fluoro-7-(3-Hydroxyazetidin-1-yl)-4-Oxo-1,4-Dihydroquinoline-3-Carboxylic Acid 
National Institutes of Health

Related topics

Related topics

2 relations

Broader (1)

ABT 492

Narrower (1)

WQ 3034

Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
Review
2019
Review
2019
Fluoroquinolones structural and medicinal developments (2013-2018): Where are we now?
2019
2019
Profile of a Novel Anionic Fluoroquinolone—Delafloxacin
Abstract Fluoroquinolones have been in clinical use for over 50 years with significant efficacy. However, increasing resistance… 
2019
2019
A Phase 3 Study to Compare Delafloxacin With Moxifloxacin for the Treatment of Adults With Community-Acquired Bacterial Pneumonia (DEFINE-CABP)
Abstract Background The clinical and economic burden of community-acquired bacterial pneumonia (CABP) is significant and is… 
Review
2018
Review
2018
Clinical review of delafloxacin: a novel anionic fluoroquinolone.
Delafloxacin is a novel anionic fluoroquinolone (FQ) approved for treatment of acute bacterial skin and skin structure infections… 
Highly Cited
2017
Highly Cited
2017
In Vitro Activity of Delafloxacin against Contemporary Bacterial Pathogens from the United States and Europe, 2014
ABSTRACT The in vitro activities of delafloxacin and comparator antimicrobial agents against 6,485 bacterial isolates collected… 
Highly Cited
2017
Highly Cited
2017
Efficacy and safety of delafloxacin compared with vancomycin plus aztreonam for acute bacterial skin and skin structure infections: a Phase 3, double-blind, randomized study
Abstract Background Delafloxacin is an investigational anionic fluoroquinolone in development for oral or intravenous… 
Review
2017
Review
2017
New and improved? A review of novel antibiotics for Gram-positive bacteria.
Highly Cited
2013
Highly Cited
2013
A Combined Pharmacodynamic Quantitative and Qualitative Model Reveals the Potent Activity of Daptomycin and Delafloxacin against Staphylococcus aureus Biofilms
ABSTRACT Biofilms are associated with persistence of Staphylococcus aureus infections and therapeutic failures. Our aim was to… 
Review
2012
Review
2012
Improving known classes of antibiotics: an optimistic approach for the future.
  • K. Bush
  • Current opinion in pharmacology (Print)
  • 2012
  • Corpus ID: 36345077
Highly Cited
2010
Highly Cited
2010
Contrasting Effects of Acidic pH on the Extracellular and Intracellular Activities of the Anti-Gram-Positive Fluoroquinolones Moxifloxacin and Delafloxacin against Staphylococcus aureus
ABSTRACT In contrast to currently marketed fluoroquinolones, which are zwitterionic, delafloxacin is an investigational… 
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