Mutations in 23S rRNA are associated with clarithromycin resistance in Helicobacter pylori
- J. Versalovic, D. Shortridge, M. Go
- Biology, MedicineAntimicrobial Agents and Chemotherapy
- 1 February 1996
This study is the first to report mutations in H. pylori associated with resistance to an antimicrobial agent used in established peptic ulcer treatment regimens and shows no polymorphisms in a conserved loop within domain V of 23S rRNA.
Meropenem-Vaborbactam Tested against Contemporary Gram-Negative Isolates Collected Worldwide during 2014, Including Carbapenem-Resistant, KPC-Producing, Multidrug-Resistant, and Extensively…
- M. Castanheira, M. Huband, R. Mendes, R. Flamm
- Biology, MedicineAntimicrobial Agents and Chemotherapy
- 26 June 2017
Meropenem-vaborbactam was active against contemporary Enterobacteriaceae isolates collected worldwide, and this combination demonstrated enhanced activity compared to those of meropenem and most comparator agents against CRE isolates and KPC producers, the latter of which are often MDR.
Fluoroquinolone Resistance in Streptococcus pneumoniae in United States since 1994-1995
- A. Brueggemann, S. Coffman, G. Doern
- Biology, MedicineAntimicrobial Agents and Chemotherapy
- 1 March 2002
Comparisons of the MIC frequency distributions of the study drugs against the isolates obtained during the three sampling periods encompassing this investigation revealed no evidence of changes in the in vitro activities of the fluoroquinolones.
Antimicrobial susceptibility of Gram-negative organisms isolated from patients hospitalized in intensive care units in United States and European hospitals (2009-2011).
- H. Sader, D. Farrell, R. Flamm, Ronald N. Jones
- Biology, MedicineDiagnostic microbiology and infectious disease
- 1 April 2014
Antimicrobial susceptibility of Gram-negative organisms isolated from patients hospitalised with pneumonia in US and European hospitals: results from the SENTRY Antimicrobial Surveillance Program,…
- H. Sader, D. Farrell, R. Flamm, Ronald N. Jones
- Medicine, BiologyInternational Journal of Antimicrobial Agents
- 1 April 2014
Point mutations in the 23S rRNA gene of Helicobacter pylori associated with different levels of clarithromycin resistance.
- J. Versalovic, M. Osato, D. Graham
- Biology, MedicineJournal of Antimicrobial Chemotherapy
- 1 August 1997
Peptic ulcer disease recurred in a substantial proportion of patients infected with H. pylori strains containing either the A2143G or the A 2144G mutation.
Characterization and Prevalence of MefA, MefE, and the Associated msr(D) Gene in Streptococcus pneumoniae Clinical Isolates
- Melissa M. Daly, S. Doktor, R. Flamm, D. Shortridge
- BiologyJournal of Clinical Microbiology
- 1 August 2004
The results of this work demonstrated that mef(A) is more often isolated in parts of Europe, with some incidence in Canada, and that the msr-like gene alone can confer the efflux phenotype.
Studies of the Novel Ketolide ABT-773: Transport, Binding to Ribosomes, and Inhibition of Protein Synthesis inStreptococcus pneumoniae
- J. Capobianco, Z. Cao, V. Shortridge, Zhen-wu Ma, R. Flamm, P. Zhong
- BiologyAntimicrobial Agents and Chemotherapy
- 1 June 2000
The ketolide ABT-773, which has a 3-keto group and no l-cladinose sugar, represents a new class of drugs with in vitro activity against a variety of resistant bacteria, and demonstrated tighter ribosome binding of ABt-773 than erythromycin.
A PCR-oligonucleotide ligation assay to determine the prevalence of 23S rRNA gene mutations in clarithromycin-resistant Helicobacter pylori
- G. Stone, D. Shortridge, S. Tanaka
- Biology, MedicineAntimicrobial Agents and Chemotherapy
- 1 March 1997
A rapid PCR-oligonucleotide ligation assay that can discriminate single base substitutions that are associated with clarithromycin resistance in Helicobacter pylori is developed.
Affinity of Doripenem and Comparators to Penicillin-Binding Proteins in Escherichia coli and Pseudomonas aeruginosa
- T. Davies, Wenchi Shang, K. Bush, R. Flamm
- BiologyAntimicrobial Agents and Chemotherapy
- 4 February 2008
Doripenem exhibited high affinity for penicillin-binding protein 2 (PBP2) and PBP3 in Pseudomonas aeruginosa and P BP2 in Escherichia coli, the primary PBPs whose inhibition leads to cell death.
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