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deferiprone
Known as:
1,2-dimethyl-3-hydroxypyrid-4-one
, DMOHPO
, 1,2-dimethyl-3-hydroxypyridin-4-one
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An orally bioavailable bidentate ligand with iron chelating activity. Deferiprone binds to iron in a 3:1 (ligand:iron) molar ratio. By binding to…
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National Institutes of Health
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Related topics
Related topics
7 relations
Narrower (3)
CP20 (deferiprone)
Ferriprox
PL-1
Iron Chelating Activity [MoA]
deferiprone 500 MG Oral Tablet [Ferriprox]
Broader (2)
Iron Chelating Agents
Pyridones
Papers overview
Semantic Scholar uses AI to extract papers important to this topic.
2010
2010
Deferiprone Is Associated with Lower Serum Ferritin (SF) Relative to Liver Iron Concentration (LIC) Than Deferoxamine and Deferasirox- Implications for Clinical Practice
Ai Leen Ang
,
Farrukh T Shah
,
+5 authors
J. Porter
2010
Corpus ID: 70877488
Abstract 4246 Introduction Serum ferritin (SF) is typically used as a surrogate marker for body iron load in thalassemia major…
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2010
2010
Deferiprone challenge test for monitoring iron overload in hepatitis positive thalassemic major patients.
D. A. Khan
,
Asma N. Cheema
,
Masood Anwar
,
F. Khan
International Journal of Clinical and…
2010
Corpus ID: 22743427
Viral hepatitis is common among beta-thalassemia major (BTM) children in Pakistan. Transfusional iron overload in BTM is usually…
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2007
2007
Complications of Combined Treatment with Deferiprone and Desferrioxamine in Thalassemic Patients
P. Eshghi
2007
Corpus ID: 59450965
Although successful iron chelation with deferiprone is associated with significant complications, patient’s compliance with…
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2005
2005
Quantitative evaluation of oxidative stress status on peripheral blood in β‐thalassaemic patients by means of electron paramagnetic resonance spectroscopy
A. Filosa
,
L. Valgimigli
,
+14 authors
M. Paolini
British Journal of Haematology
2005
Corpus ID: 20619420
High oxidative stress status (OSS) is known to be one of the most important factors determining cell injury and consequent organ…
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2004
2004
Deferiprone (L1) induced conformation change of hemoglobin: A fluorescence and CD spectroscopic study
D. Chakraborty
,
M. Bhattacharyya
Molecular and Cellular Biochemistry
2004
Corpus ID: 2369253
The interaction of deferiprone (1,2-dimethyl-3-hydroxy-pyrid-4-one) L1, the first clinically available oral iron chelator, with…
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2002
2002
The Olivieri dispute: no end in sight?
M. Shuchman
CMAJ : Canadian Medical Association journal…
2002
Corpus ID: 38349590
The story of the battle between Dr. Nancy Olivieri and the drug company Apotex is well known: the company produced an…
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1999
1999
Japan celebrates ten years of the HFSP
R. Nathan
Nature Network Boston
1999
Corpus ID: 44839952
The Human Frontier Science Program (HFSP), which supports international research on molecular biology and neuroscience…
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1998
1998
Iron chelation with oral deferiprone in patients with thalassemia.
F. Callea
New England Journal of Medicine
1998
Corpus ID: 37476979
1985
1985
Site specificity of iron removal from transferrin by alpha-ketohydroxypyridine chelators.
G. Kontoghiorghes
,
R. W. Evans
FEBS Letters
1985
Corpus ID: 6893452
The site specificity of the removal of iron from diferric human transferrin, at pH 7.4, by two alpha-ketohydroxypyridine…
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1977
1977
Anticoccidial 1-substituted 4(1H)-pyridinone hydrazones.
A. W. Douglas
,
M. Fisher
,
+5 authors
W. V. Ruyle
Journal of Medicinal Chemistry
1977
Corpus ID: 39250724
4-Chlorobenzaldehyde 1-(4-chlorophenyl)-4(1H)-pyridinylidene hydrazone fluorusulfonate (4) was found to have excellent…
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