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deferasirox

Known as: deferasirox [Chemical/Ingredient], 4-(3,5-bis-(2-hydroxyphenyl)-(1,2,4)-triazol-1-yl)benzoic acid, 4-(3,5-Bis-(hydroxy-phenyl)-1,2,4-triazol-1-yl)-benzoic Acid 
A drug used to treat too much iron in the blood caused by blood transfusions. It is being studied in the treatment of myelodysplastic syndromes (a… Expand
National Institutes of Health

Papers overview

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Highly Cited
2010
Highly Cited
2010
Background Following a clinical evaluation of deferasirox (Exjade®) it was concluded that, in addition to baseline body iron… Expand
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Highly Cited
2010
Highly Cited
2010
Cardiac iron overload causes most deaths in beta-thalassemia major. The efficacy of deferasirox in reducing or preventing cardiac… Expand
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Highly Cited
2009
Highly Cited
2009
Objective:  Many patients with transfusional iron overload are at risk for progressive organ dysfunction and early death and poor… Expand
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Highly Cited
2008
Highly Cited
2008
Objectives/methods:  This 1‐yr prospective phase II trial evaluated the efficacy of deferasirox in regularly transfused patients… Expand
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Highly Cited
2007
Highly Cited
2007
Deferasirox is a once‐daily, oral iron chelator developed for treating transfusional iron overload. Preclinical studies indicated… Expand
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Highly Cited
2007
Highly Cited
2007
Mucormycosis causes mortality in at least 50% of cases despite current first-line therapies. Clinical and animal data indicate… Expand
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Highly Cited
2007
Highly Cited
2007
BACKGROUND Iron chelation therapy (ICT) with deferoxamine (DFO), the current standard for the treatment of iron overload in… Expand
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Highly Cited
2006
Highly Cited
2006
Deferasirox (ICL670) is a once-daily oral iron chelator developed for the treatment of chronic iron overload from blood… Expand
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Review
2006
Review
2006
For nearly 30 years, patients with transfusional iron overload have depended on nightly deferoxamine infusions for iron chelation… Expand
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Highly Cited
2006
Highly Cited
2006
BACKGROUND AND OBJECTIVES Iron accumulation is an inevitable consequence of chronic blood transfusions and results in serious… Expand
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