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darusentan

Known as: (+)-(S)-2-((4,6-dimethoxy-2-pyrimidinyl)oxy)-3-methoxy-3,3-diphenylpropionic acid, benzenepropanoic acid, alpha-((4,6-dimethoxy-2-pyrimidinyl)oxy)-beta-methoxy-beta-phenyl-, (S)- 
National Institutes of Health

Papers overview

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Highly Cited
2010
Highly Cited
2010
Patients with resistant hypertension are at increased risk for cardiovascular events. The addition of new treatments to existing… Expand
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Review
2010
Review
2010
Resistant hypertension is commonly found in everyday clinical practice. However, the risks of resistant hypertension, as well as… Expand
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Highly Cited
2010
Highly Cited
2010
To evaluate potential mechanisms of clinical hepatotoxicity, 4 endothelin receptor antagonists (ERAs) were examined for substrate… Expand
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Highly Cited
2009
Highly Cited
2009
BACKGROUND Hypertension cannot always be adequately controlled with available drugs. We investigated the blood-pressure-lowering… Expand
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Highly Cited
2007
Highly Cited
2007
In this phase 2, randomized, double‐blind, placebo‐controlled forced dose‐titration study, 115 patients with resistant… Expand
Review
2006
Review
2006
Since its initial characterization in 1988, over 18,236 papers, including 2,485 reviews, have been published in the endothelin… Expand
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Highly Cited
2004
Highly Cited
2004
BACKGROUND Endothelin-receptor blockade provides haemodynamic benefit in experimental and clinical heart failure. We aimed to… Expand
Highly Cited
2004
Highly Cited
2004
The cause of focal-segmental glomerulosclerosis as a consequence of physiological aging, which is believed to be inexorable, is… Expand
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Highly Cited
2002
Highly Cited
2002
BACKGROUND The antihypertensive efficacy and safety of darusentan, a new selective endothelin, antagonist was investigated… Expand
Highly Cited
2002
Highly Cited
2002
Background—The endothelin (ET-1) system is activated in chronic heart failure (CHF). Whether, what type, and what degree of… Expand
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