darusentan

Known as: (+)-(S)-2-((4,6-dimethoxy-2-pyrimidinyl)oxy)-3-methoxy-3,3-diphenylpropionic acid, benzenepropanoic acid, alpha-((4,6-dimethoxy-2-pyrimidinyl)oxy)-beta-methoxy-beta-phenyl-, (S)- 
 

Topic mentions per year

Topic mentions per year

2001-2016
0246820012016

Papers overview

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Highly Cited
2010
Highly Cited
2010
Patients with resistant hypertension are at increased risk for cardiovascular events. The addition of new treatments to existing… (More)
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2010
2010
To evaluate potential mechanisms of clinical hepatotoxicity, 4 endothelin receptor antagonists (ERAs) were examined for substrate… (More)
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Highly Cited
2009
Highly Cited
2009
BACKGROUND Hypertension cannot always be adequately controlled with available drugs. We investigated the blood-pressure-lowering… (More)
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2007
2007
In this phase 2, randomized, double-blind, placebo-controlled forced dose-titration study, 115 patients with resistant… (More)
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2006
2006
The exaggerated cardiac arrhythmias in cardiomyopathy induced by L-thyroxine treatment are related to ion channelopathies and to… (More)
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Highly Cited
2004
Highly Cited
2004
BACKGROUND Endothelin-receptor blockade provides haemodynamic benefit in experimental and clinical heart failure. We aimed to… (More)
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2002
2002
BACKGROUND The antihypertensive efficacy and safety of darusentan, a new selective endothelin, antagonist was investigated… (More)
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2002
2002
BACKGROUND The endothelin (ET-1) system is activated in chronic heart failure (CHF). Whether, what type, and what degree of… (More)
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2002
2002
OBJECTIVES AND DESIGN Isolated systolic hypertension (ISH) is the predominant form of hypertension in the elderly population and… (More)
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2002
2002
In heart failure, the cGMP to natriuretic peptide ratio is decreased and infusion of atrial natriuretic peptide (ANP) induces… (More)
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