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Patients with resistant hypertension are at increased risk for cardiovascular events. The addition of new treatments to existing… Expand Resistant hypertension is commonly found in everyday clinical practice. However, the risks of resistant hypertension, as well as… Expand To evaluate potential mechanisms of clinical hepatotoxicity, 4 endothelin receptor antagonists (ERAs) were examined for substrate… Expand BACKGROUND
Hypertension cannot always be adequately controlled with available drugs. We investigated the blood-pressure-lowering… Expand In this phase 2, randomized, double‐blind, placebo‐controlled forced dose‐titration study, 115 patients with resistant… Expand Since its initial characterization in 1988, over 18,236 papers, including 2,485 reviews, have been published in the endothelin… Expand BACKGROUND
Endothelin-receptor blockade provides haemodynamic benefit in experimental and clinical heart failure. We aimed to… Expand The cause of focal-segmental glomerulosclerosis as a consequence of physiological aging, which is believed to be inexorable, is… Expand BACKGROUND
The antihypertensive efficacy and safety of darusentan, a new selective endothelin, antagonist was investigated… Expand Background—The endothelin (ET-1) system is activated in chronic heart failure (CHF). Whether, what type, and what degree of… Expand