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darusentan

Known as: (+)-(S)-2-((4,6-dimethoxy-2-pyrimidinyl)oxy)-3-methoxy-3,3-diphenylpropionic acid, benzenepropanoic acid, alpha-((4,6-dimethoxy-2-pyrimidinyl)oxy)-beta-methoxy-beta-phenyl-, (S)- 
National Institutes of Health

Related topics

Related topics

4 relations

Broader (3)

Endothelin receptor antagonistPhenylpropionatesPyrimidines

Narrower (1)

LU 135252

Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
2010
2010
Endothelin receptor antagonists in proteinuric renal disease: every rose has its thorn.
When Yanagisawa et al. 1 first identified endothelin (ET), a novel polypeptide vasoconstrictor for which numerous other functions… 
2008
2008
Efficacy and Safety of Darusentan: A Novel Endothelin Receptor Antagonist
Objective: To summarize the role of the endothelin system (ETS) in cardiovascular disease (CVD) and evaluate the potential… 
2008
2008
Endothelin receptor antagonism: what does the future hold?
The endothelins are a family (ET-1, ET-2, and ET-3) of naturally occurring polypeptides, with ET-1 being the most clinically… 
2006
2006
Spironolactone preserves cardiac norepinephrine reuptake in salt-sensitive Dahl rats.
An impairment of cardiac norepinephrine (NE) reuptake via the neuronal NE transporter (NET) enhances the effects of increased… 
2003
2003
Effects of the Endothelin A Receptor Antagonist Darusentan on Blood Pressure and Vascular Contractility in Type 2 Diabetic Goto-Kakizaki Rats
The present study evaluated the effects of long-term treatment with the endothelin A (ETA) receptor antagonist darusentan… 
2003
2003
Renal damage is not improved by blockade of endothelin receptors in primary renin-dependent hypertension
Objective Secondary activation of the renin–angiotensin system plays a major role in the progression of chronic nephropathies… 
2002
2002
Endothelin A-receptor antagonist administration immediately after experimental myocardial infarction with reperfusion does not affect scar healing in dogs.
Highly Cited
2002
Highly Cited
2002
Pharmacological prevention and regression of arterial remodeling in a rat model of isolated systolic hypertension
Objectives and design Isolated systolic hypertension (ISH) is the predominant form of hypertension in the elderly population and… 
2002
2002
Effects of obesity on endothelium-dependent reactivity during acute nitric oxide synthase inhibition: modulatory role of endothelin.
This study investigated vascular reactivity in response to acetylcholine, in the presence of acute inhibition of nitric oxide… 
Highly Cited
2001
Highly Cited
2001
Norepinephrine-induced aortic hyperplasia and extracellular matrix deposition are endothelin-dependent
Background Sympathetic hyperactivity is observed in several disease states and may contribute to cardiovascular hypertrophic… 
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