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darusentan

Known as: (+)-(S)-2-((4,6-dimethoxy-2-pyrimidinyl)oxy)-3-methoxy-3,3-diphenylpropionic acid, benzenepropanoic acid, alpha-((4,6-dimethoxy-2-pyrimidinyl)oxy)-beta-methoxy-beta-phenyl-, (S)- 
National Institutes of Health

Related topics

Related topics

4 relations

Broader (3)

Endothelin receptor antagonistPhenylpropionatesPyrimidines

Narrower (1)

LU 135252

Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
2010
2010
An endothelin antagonist for resistant hypertension
2008
2008
Efficacy and Safety of Darusentan: A Novel Endothelin Receptor Antagonist
Objective: To summarize the role of the endothelin system (ETS) in cardiovascular disease (CVD) and evaluate the potential… 
2008
2008
Endothelin receptor antagonism: what does the future hold?
The endothelins are a family (ET-1, ET-2, and ET-3) of naturally occurring polypeptides, with ET-1 being the most clinically… 
2006
2006
Deconstructing Myogen's market cap
The best-performing stock from 2005 was a prime example of how biotech stocks are not as capricious as they may seem. 
Review
2004
Review
2004
Endothelin receptor antagonists in heart failure: current status and future directions.
Experimental evidence suggests that endothelin substantially contributes to left ventricular remodelling and progression of heart… 
2004
2004
Neurohumoral and hemodynamic effects of the selective endothelin antagonist darusentan in advanced chronic heart failure.
2003
2003
Renal damage is not improved by blockade of endothelin receptors in primary renin-dependent hypertension
Objective Secondary activation of the renin–angiotensin system plays a major role in the progression of chronic nephropathies… 
Highly Cited
2002
Highly Cited
2002
Pharmacological prevention and regression of arterial remodeling in a rat model of isolated systolic hypertension
Objectives and design Isolated systolic hypertension (ISH) is the predominant form of hypertension in the elderly population and… 
2002
2002
Endothelin A-receptor antagonist administration immediately after experimental myocardial infarction with reperfusion does not affect scar healing in dogs.
2002
2002
Effects of obesity on endothelium-dependent reactivity during acute nitric oxide synthase inhibition: modulatory role of endothelin.
This study investigated vascular reactivity in response to acetylcholine, in the presence of acute inhibition of nitric oxide… 
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