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LU 135252

Known as: LU-135252 
National Institutes of Health

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darusentan

Papers overview

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2008
2008
Inhalation of the ETA receptor antagonist LU-135252 selectively attenuates hypoxic pulmonary vasoconstriction.
Endogenous endothelin (ET)-1 modulates hypoxic pulmonary vasoconstriction (HPV). Accordingly, intravenously applied ET(A… 
2006
2006
Endothelin-1 Receptor Antagonist (LU-135252) Improves the Microcirculation and Course of TNBS Colitis in Rats
The role of microcirculation in the pathogenesis and course of chronic inflammatory bowel disease is still unclear. The aim of… 
2004
2004
Endothelin receptor antagonists are not beneficial in the therapy of acute experimental pancreatitis
Background and aimDue to increased capillary permeability and the early appearance of vasoactive and toxic agents, patients… 
2004
2004
Inhalation of the Endothelin-A Receptor Antagonist LU-135252 at Various Doses in Experimental Acute Lung Injury
We studied the effects of the inhaled endothelin-A receptor antagonist LU-135252 at different doses on hemodynamics and gas… 
2003
2003
Effects of ET-A receptor blockade on eNOS gene expression in chronic hypoxic rat lungs.
We tested the hypothesis that pulmonary endothelial nitric oxide synthase (eNOS) gene expression is primarily regulated by… 
2002
2002
The inhaled ET(A) receptor antagonist LU-135252 acts as a selective pulmonary vasodilator.
To investigate the hypothesis that the inhaled ET(A) receptor antagonist LU-135252 acts as selective pulmonary vasodilator, we… 
2001
2001
Hemodynamic, renal, and endocrine responses to acute ET(A) blockade at different ANG II plasma levels.
Angiotensin (ANG) II effects may be partly mediated by endothelin (ET)-1. This study analyses the hemodynamic, renal, and… 
2000
2000
Role of ETA receptors in the regulation of vascular reactivity in rats with congestive heart failure
Endothelium-derived nitric oxide (NO) and endothelin (ET)-1 interact to regulate vascular tone. In congestive heart failure (CHF… 
2000
2000
Role of ET(A) receptors in the regulation of vascular reactivity in rats with congestive heart failure.
Endothelium-derived nitric oxide (NO) and endothelin (ET)-1 interact to regulate vascular tone. In congestive heart failure (CHF… 
1999
1999
Contribution of endothelin to renal vascular tone and autoregulation in the conscious dog.
Exogenous endothelin-1 (ET-1) is a strong vasoconstrictor in the canine kidney and causes a decrease in renal blood flow (RBF) by… 
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