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dactolisib

Known as: 2-methyl-2-(4-(3-methyl-2-oxo-8-(quinolin-3-yl)-2,3-dihydroimidazo(4,5-c)quinolin-1-yl)phenyl)propanenitrile, 2-methyl-2-(4-(3-methyl-2-oxo-8-quinolin-3-yl-2,3-dihydro-1h-imidazo(4,5-c)quinolin-1-yl)phenyl)propanenitrile 
National Institutes of Health

Related topics

Related topics

5 relations

Broader (3)

Antineoplastic AgentsImidazolesQuinolines

Narrower (2)

BEZ235NVP BEZ235

Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
2019
2019
Oral TORC1 Inhibitor Dactolisib Enhances Immune Function and Reduces the Incidence of Respiratory Tract Infections in Elderly Subjects with Asthma
2018
2018
Symbolic Regression Modeling of Drug Responses
Big pharmaceutical companies require to innovate by applying new machine learning and artificial intelligence methods to… 
2018
2018
Correction: The dual PI3K/mTOR inhibitor dactolisib elicits anti-tumor activity in vitro and in vivo
[This corrects the article DOI: 10.18632/oncotarget.23091.]. 
2017
2017
Biological characterization of SN 32976 , a selective inhibitor of PI 3 K and mTOR with preferential activity to PI 3 K α , in comparison to established pan PI 3 K inhibitors
Multiple therapeutic agents have been developed to target the phosphatidylinositol 3-kinase (PI3K) signaling pathway, which is… 
2017
2017
DACTOLISIB-LOADED RECONSTITUTED HIGH DENSITY LIPOPROTEINS (RHDAL): A CANDIDATE FOR GLIOBLASTOMA THERAPY
Despite substantial chemotherapeutic advances in the 21st century, toxicity remains a prevailing obstacle in cancer treatment… 
2017
2017
Methods of enhancing immune response with everolimus, dactolisib or both
2016
2016
Dactolisib (NVP-BEZ235) toxicity in murine brain tumour models
Glioblastomas (GBMs) are highly malignant brain tumours with a poor prognosis, and current cytotoxic regimens provide only a… 
2015
2015
Trametinib and dactolisib but not regorafenib exert antiproliferative effects on rat pancreatic stellate cells.
2015
2015
GENO-26IDENTIFICATION OF GENOMIC LESIONS ENRICHED IN LUNG CANCER BRAIN METASTASES
BACKGROUND: The incidence of central nervous system metastasis from primary non-small cell lung cancer (NSCLC) has steadily… 
2014
2014
Characterization of BK viral responses to the dual-PI3K/MTOR inhibitor dactolisib (NVP BEZ-235) in a renal cell culture model
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