BEZ235

Known as: PI3K/mTOR Inhibitor BEZ235 
An orally bioavailable imidazoquinoline targeting the phosphatidylinositol 3 kinase (PI3K) and the mammalian target of rapamycin (mTOR), with… (More)
National Institutes of Health

Papers overview

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Highly Cited
2014
Highly Cited
2014
The PI3K/Akt/mTOR pathway has a central role in cancer metastasis and radiotherapy. To develop effective therapeutics to improve… (More)
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Highly Cited
2013
Highly Cited
2013
Radioresistance is a major challenge in prostate cancer (CaP) radiotherapy (RT). In this study, we investigated the role and… (More)
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2013
2013
Hemopoietic progenitor cells (HPC) from myeloproliferative neoplasms (MPN) such as myelofibrosis commonly express mutant JAK2… (More)
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Highly Cited
2012
Highly Cited
2012
PURPOSE Gene mutations along the Ras pathway (KRAS, NRAS, BRAF, PIK3CA) occur in approximately 50% of colorectal cancers (CRC… (More)
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Highly Cited
2011
Highly Cited
2011
Oncogene activation has been shown to generate replication-born DNA damage, also known as replicative stress. The primary… (More)
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Highly Cited
2011
Highly Cited
2011
The PI3K pathway is frequently activated in cancer; therefore, considerable effort is focused on identifying compounds that can… (More)
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Highly Cited
2010
Highly Cited
2010
Although the phosphatidylinositol 3-kinase to Akt to mammalian target of rapamycin (PI3K-Akt-mTOR) pathway promotes survival… (More)
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Highly Cited
2010
Highly Cited
2010
The malignant brain cancer medulloblastoma is characterized by mutations in Hedgehog (Hh) signaling pathway genes, which lead to… (More)
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Highly Cited
2009
Highly Cited
2009
Non-small cell lung cancers with activating mutations in the epidermal growth factor receptor (EGFR) are highly responsive to… (More)
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Highly Cited
2009
Highly Cited
2009
Non-small cell lung cancer (NSCLC) is a leading cause of cancer-related death worldwide. NSCLC often harbors oncogenic K-RAS… (More)
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