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dabrafenib
Known as:
Benzenesulfonamide, N-(3-(5-(2-amino-4-pyrimidinyl)-2-(1,1-dimethylethyl)-4-thiazolyl)-2-fluorophenyl)-2,6-difluoro-
An orally bioavailable inhibitor of B-raf (BRAF) protein with potential antineoplastic activity. Dabrafenib selectively binds to and inhibits the…
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National Institutes of Health
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Related topics
Related topics
11 relations
Broader (4)
Antineoplastic Agents
Imidazoles
Oximes
Protein Kinase Inhibitors
Breast Cancer Resistance Protein Inhibitors [MoA]
NCIt Antineoplastic Agent Terminology
Organic Anion Transporter 1 Inhibitors [MoA]
dabrafenib 75 MG Oral Capsule [Tafinlar]
Narrower (3)
GSK 2118436
Tafinlar
dabrafenib mesylate
Papers overview
Semantic Scholar uses AI to extract papers important to this topic.
2018
2018
Melanoma: Time for adjuvant vemurafenib?
Diana Romero
Nature Reviews Clinical Oncology
2018
Corpus ID: 3882017
2018
2018
Melanoma: Neo/adjuvant BRAF/MEKi improves outcomes
P. Sidaway
Nature Reviews Clinical Oncology
2018
Corpus ID: 3427440
2018
2018
Efficacy Outcomes in the Phase 3 COMBI-AD Study of Adjuvant Dabrafenib Plus Trametinib vs Placebo in Patients with Stage III BRAFV600E/K-Mutant Melanoma
G. Long
,
A. Hauschild
,
+20 authors
J. Kirkwood
2018
Corpus ID: 57720806
Abstract not available. Disclosures: Study sponsored by Novartis. Copyright 2018 SKIN
2017
2017
Dabrafenib Effective in Pediatric Glioma.
Cancer Discovery
2017
Corpus ID: 27376769
A phase I/II clinical trial suggests that dabrafenib shrinks or stabilizes low-grade gliomas in children with the BRAF V600E…
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2016
2016
Phase 2 study of the safety and efficacy of pembrolizumab (pembro) in combination with dabrafenib (D) and trametinib (T) for advanced melanoma (KEYNOTE-022).
G. Long
,
O. Hamid
,
+16 authors
A. Ribas
2016
Corpus ID: 56780039
TPS9596Background: The interaction between programmed death 1 (PD-1) and its ligands PD-L1 and PD-L2 represents a major pathway…
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Review
2015
Review
2015
Evolution of melanocytic nevi under vemurafenib, followed by combination therapy with dabrafenib and trametinib for metastatic melanoma.
C. Giurcaneanu
,
C. Nitipir
,
L. Popa
,
A. Forsea
,
I. Popescu
,
Roxana Silvia Bumbăcea
Acta dermatovenerologica Croatica : ADC
2015
Corpus ID: 6600707
Treatment of advanced melanoma with selective BRAF and MEK inhibitors is associated with a series of mucocutaneous side effects…
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Review
2014
Review
2014
Trametinib plus dabrafenib for unresectable or metastatic melanoma with BRAF V600E or V600K mutations
J. Abraham
2014
Corpus ID: 74858407
O n January 9, 2014, the combination of trametinib and dabrafenib was granted accelerated approval by the US Food and Drug…
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2014
2014
[Targeted therapies for melanoma].
Claus Garbe
,
F. Meier
,
T. Eigentler
Der Hautarzt; Zeitschrift fur Dermatologie…
2014
Corpus ID: 73735491
Since the discovery of activating mutations in the BRAF oncogene and also stimulation of immune mediated antitumor response in…
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2012
2012
Hauschild A, Grob JJ, Demidov LV et al.Dabrafenib in BRAF-mutated metastatic melanoma: a multicentre, open-label, phase 3 randomised controlled trial. Lancet 380:358-365
A. Hauschild
,
J. Grob
,
+18 authors
P. Chapman
2012
Corpus ID: 87827551
2012
2012
New class of kinase inhibitors poised to join the anticancer arsenal
Alisa Opar
Nature reviews. Drug discovery
2012
Corpus ID: 5632297
Long-standing efforts to develop drugs that target MEKs could soon come to fruition, moving the frontier to how best to combine…
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