Skip to search formSkip to main contentSkip to account menu

dUTP pyrophosphatase

Known as: dUTPase, deoxyuridine triphosphate nucleotidylhydrolase, deoxyuridinetriphosphatase 
National Institutes of Health

Related topics

Related topics

2 relations
DUT gene

Broader (1)

pyrophosphatase

Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
2016
2016
Exploiting nucleotide metabolism to improve cancer therapy : by targeting dUTPase, dCTPase and NUDT15
Synthetic nucleobaseand nucleoside-analogs have stood the test of time and remain a cornerstone in the treatment regimen against… 
2014
2014
Target characterization and ligand design directed at deoxyuridine 5'-triphospate nucleotidohydrolase
dUTPase is an important enzyme in DNA metabolism. It can be thought of as a gate keeper for apoptosis and is therefore an… 
2011
2011
TTP binding in the active conformation of dCTP deaminase:dUTPase
C792 at 2.4 Å and 2.25 Å, respectively. This is the first reported structure of a prokaryotic UCK. The overall structure is… 
2008
2008
Characterization of Kaposi's Sarcoma-Associated Herpes Virus ORF 11 as a Possible dUTPASE
A dUTPase is a crucial enzyme that hydrolyzes dUTP to dUMP. This reaction prevents the mutagenic or lethal misincorporation of… 
2007
2007
An in silico study to understand the factors which are important for the rational design of novel inhibitors of dUTPase, an antimalarial drug target
Inhibition of deoxyuridine triphosphate dUTPase, a ubiquitous enzyme and 'first line' of defence against misincorporation of… 
2006
2006
Supplementary Information Legends to Supplementary Figures Supplementary Figure 1 Phenotypes associated with dut-1(RNAi) in the N2 strain. The severity of the phenotypes arising from depletion of…
  • 2006
  • Corpus ID: 33363133
2005
2005
Design and synthesis of potential inhibitors against dUTPase, a novel drug target for the control of protozoal and bacterial infections.
The enzyme deoxyuridine triphosphate nucleotidohydrolase (dUTPase) is a ubiquitous enzyme that can be considered as the first… 
2002
2002
Structural studies of Drosophila melanogaster dUTPase
Deoxyuridine triphosphate nucleotidohydrolases (dUTPases) play a unique preventive role in DNA repair by excluding uracil from… 
1999
1999
Crystallization and preliminary X-ray diffraction of Trypanosoma cruzi dUTPase.
Crystals of Trypanosoma cruzi dUTPase have been grown. Two different morphologies are observed, depending on the molecular weight… 
1979
1979
STUDIES ON DEOXYURIDINE TRIPHOSPHATE NUCLEOTIDOHYDROLASE (DUTPASE) AND THE REGULATION OF INTRACELLULAR DUTP LEVELS DURING THE HELA CELL CYCLE