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dUTP pyrophosphatase

Known as: dUTPase, deoxyuridine triphosphate nucleotidylhydrolase, deoxyuridinetriphosphatase 
National Institutes of Health

Papers overview

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Highly Cited
2004
Highly Cited
2004
dUTPase is essential to keep uracil out of DNA. Crystal structures of substrate (dUTP and α,β-imino-dUTP) and product complexes… Expand
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Review
2001
Review
2001
  • R. Ladner
  • Current protein & peptide science
  • 2001
  • Corpus ID: 24643850
Thymidylate metabolism is an important target for chemotherapeutic agents that combat a variety of neoplastic diseases including… Expand
Highly Cited
1996
Highly Cited
1996
The enzyme dUTPase catalyzes the hydrolysis of dUTP to dUMP and pyrophosphate, thereby preventing a deleterious incorporation of… Expand
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Highly Cited
1995
Highly Cited
1995
As an important enzyme in DNA synthesis, dUTPase is present in a wide variety of organisms and viruses and has been identified as… Expand
Highly Cited
1993
Highly Cited
1993
dUTP pyrophosphatase (dUTPase; EC 3.6.1.23) catalyses the hydrolysis of dUTP to dUMP and PPi and thereby prevents the… Expand
Highly Cited
1992
Highly Cited
1992
THE enzyme dUTPase catalyses the hydrolysis of dUTP1 and maintains a low intracellular concentration of dUTP so that uracil… Expand
Highly Cited
1987
Highly Cited
1987
Publisher Summary This chapter focuses on rapid and efficient site-specific mutagenesis without phenotypic selection. The… Expand
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Highly Cited
1982
Highly Cited
1982
Studies of trpA reversions revealed that G:C leads to A:T transitions were stimulated about 30-fold in E. coli ung mutants… Expand
Highly Cited
1977
Highly Cited
1977
Strains of Escherichia coli with a mutation in the sof (dnaS) locus show a higher than normal frequency of recombination (are… Expand
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Highly Cited
1977
Highly Cited
1977
Mutants of Escherichia coli that are severely defective in the enzyme dUTPase (dut) accumulate short (4 to 5 S) Okazaki fragments… Expand
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