Semantic Scholar uses AI to extract papers important to this topic.
dUTPase is essential to keep uracil out of DNA. Crystal structures of substrate (dUTP and α,β-imino-dUTP) and product complexes… Expand Thymidylate metabolism is an important target for chemotherapeutic agents that combat a variety of neoplastic diseases including… Expand The enzyme dUTPase catalyzes the hydrolysis of dUTP to dUMP and pyrophosphate, thereby preventing a deleterious incorporation of… Expand As an important enzyme in DNA synthesis, dUTPase is present in a wide variety of organisms and viruses and has been identified as… Expand dUTP pyrophosphatase (dUTPase; EC 18.104.22.168) catalyses the hydrolysis of dUTP to dUMP and PPi and thereby prevents the… Expand THE enzyme dUTPase catalyses the hydrolysis of dUTP1 and maintains a low intracellular concentration of dUTP so that uracil… Expand Publisher Summary
This chapter focuses on rapid and efficient site-specific mutagenesis without phenotypic selection. The… Expand Studies of trpA reversions revealed that G:C leads to A:T transitions were stimulated about 30-fold in E. coli ung mutants… Expand Strains of Escherichia coli with a mutation in the sof (dnaS) locus show a higher than normal frequency of recombination (are… Expand Mutants of Escherichia coli that are severely defective in the enzyme dUTPase (dut) accumulate short (4 to 5 S) Okazaki fragments… Expand